WIPM OpenIR  > 磁共振应用研究部
Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene
Wang, Shao-Ru1; Zhang, Qiu-Yan2; Wang, Jia-Qi1; Ge, Xing-Yi2; Song, Yan-Yan1; Wang, Ya-Fen1; Li, Xiao-Dan2; Fu, Bo-Shi1; Xu, Guo-Hua3; Shu, Bo2; Gong, Peng2; Zhang, Bo2; Tian, Tian1; Zhou, Xiang1
2016-09-22
Source PublicationCELL CHEMICAL BIOLOGY
Volume23Issue:9Pages:1113-1122
SubtypeArticle
AbstractIn the present study, our bioinformatics analysis first reveals the existence of a conserved guanine-rich sequence within the Zaire ebolavirus L gene. Using various methods, we show that this sequence tends to fold into G-quadruplex RNA. TMPyP4 treatment evidently inhibits L gene expression at the RNA level. Moreover, the mini-replicon assay demonstrates that TMPyP4 effectively inhibits the artificial Zaire ebolavirus mini-genome and is a more potent inhibitor than ribavirin. Although TMPyP4 treatment reduced the replication of the mutant mini-genome when G-quadruplex formation was abolished in the L gene, its inhibitory effect was significantly alleviated compared with wild-type. Our findings thus provide the first evidence that G-quadruplex RNA is present in a negative-sense RNA virus. Finally, G-quadruplex RNA stabilization may represent a new therapeutic strategy against Ebola virus disease.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.chembiol.2016.07.019
WOS KeywordDNA G-QUADRUPLEX ; C-MYC ; HIGH-THROUGHPUT ; SMALL-MOLECULE ; FORMING SEQUENCES ; DRUG DEVELOPMENT ; HUMAN GENOME ; IN-VIVO ; PROMOTER ; TRANSLATION
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000384731600013
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/9594
Collection磁共振应用研究部
Affiliation1.Wuhan Univ, Inst Adv Studies, Coll Chem & Mol Sci, Key Lab Biomed Polymers,Minist Educ, Wuhan 430072, Hubei Province, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei Province, Peoples R China
3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Hubei Province, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shao-Ru,Zhang, Qiu-Yan,Wang, Jia-Qi,et al. Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene[J]. CELL CHEMICAL BIOLOGY,2016,23(9):1113-1122.
APA Wang, Shao-Ru.,Zhang, Qiu-Yan.,Wang, Jia-Qi.,Ge, Xing-Yi.,Song, Yan-Yan.,...&Zhou, Xiang.(2016).Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene.CELL CHEMICAL BIOLOGY,23(9),1113-1122.
MLA Wang, Shao-Ru,et al."Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene".CELL CHEMICAL BIOLOGY 23.9(2016):1113-1122.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Shao-Ru]'s Articles
[Zhang, Qiu-Yan]'s Articles
[Wang, Jia-Qi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Shao-Ru]'s Articles
[Zhang, Qiu-Yan]'s Articles
[Wang, Jia-Qi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Shao-Ru]'s Articles
[Zhang, Qiu-Yan]'s Articles
[Wang, Jia-Qi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.