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NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo
Hou, Yi1; Qiao, Ruirui1; Fang, Fang2; Wang, Xuxia2; Dong, Chengyan3; Liu, Kan4,5; Liu, Chunyan1; Liu, Zhaofei3; Lei, Hao2; Wang, Fan3; Gao, Mingyuan1
2013
Source PublicationACS NANO
Volume7Issue:1Pages:330-338
SubtypeArticle
AbstractDifferently sized NaGdF4 nanocrystals with narrow particle size distributions were synthesized by a high temperature approach. Upon ligand exchange, the as-prepared hydrophobic NaGdF4 nanocrystals were transferred into water by using asymmetric PEGs simultaneously bearing phosphate and maleimide groups. Further investigations demonstrated that the water-soluble NaGdF4 nanocrystals, coated by PEG bearing two phosphate groups on the same side, exhibit not only excellent colloidal stability in water and PBS buffer, but also higher T1 relaxivity than Gd-DTPA (Magnevist). Through "click" reaction between the maleimide residue on particle surface and thiol group from the partly reduced anti-EGFR monoclonal antibody (mAb), NaGdF4 PEG-mAb nanoprobes were constructed, and their biocompatibility and binding specificity were evaluated through in vitro experiments. A series of in vivo experiments were then carried out for detecting Intraperitoneal tumor xenografts in nude mice by using magnetic resonance (MR) imaging technique. The results revealed that the NaGdF4 PEG-mAb probes possessed satisfying tumor-specific targeting ability and strong MR contrast enhancement effects.
KeywordNagdf4 Nanoparticles Ligand Exchange T1 Contrast Agent Mr Molecular Imaging Probe Intraperitoneal Tumor Xenografts
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1021/nn304837c
WOS KeywordMRI CONTRAST AGENTS ; GOLD NANOPARTICLES ; GADOLINIUM ; NANOCRYSTALS ; CANCER ; NANOPROBES ; ANTIBODY
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000314082800037
Citation statistics
Cited Times:149[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/949
Collection磁共振基础研究部
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100083, Peoples R China
4.CAMS, Canc Hosp, Beijing 100021, Peoples R China
5.PUMC, Beijing 100021, Peoples R China
Recommended Citation
GB/T 7714
Hou, Yi,Qiao, Ruirui,Fang, Fang,et al. NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo[J]. ACS NANO,2013,7(1):330-338.
APA Hou, Yi.,Qiao, Ruirui.,Fang, Fang.,Wang, Xuxia.,Dong, Chengyan.,...&Gao, Mingyuan.(2013).NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo.ACS NANO,7(1),330-338.
MLA Hou, Yi,et al."NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts in Vivo".ACS NANO 7.1(2013):330-338.
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