APM OpenIR  > 磁共振应用研究部
Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory
Yang, Ying1,2; Wang, Zhi-Hao1,2; Jin, Sen5; Gao, Di1,2; Liu, Nan3,4; Chen, Shan-Ping3,4; Zhang, Sinan5; Liu, Qing5; Liu, Enjie1,2; Wang, Xin1,2; Liang, Xiao6; Wei, Pengfei3,4; Li, Xiaoguang1,2; Li, Yin1,2; Yue, Chenyu5; Li, Hong-lian1,2; Wang, Ya-Li1,2; Wang, Qun1,2; Ke, Dan1,2; Xie, Qingguo6; Xu, Fuqiang5; Wang, Liping3,4; Wang, Jian-Zhi1,2,7
2016-07-01
Source PublicationNature Communications
Volume7
SubtypeArticle
AbstractDifferent emotional states lead to distinct behavioural consequences even when faced with the same challenging events. Emotions affect learning and memory capacities, but the underlying neurobiological mechanisms remain elusive. Here we establish models of learned helplessness (LHL) and learned hopefulness (LHF) by exposing animals to inescapable foot shocks or with anticipated avoidance trainings. The LHF animals show spatial memory potentiation with excitatory monosynaptic upscaling between posterior basolateral amygdale (BLP) and ventral hippocampal CA1 (vCA1), whereas the LHL show memory deficits with an attenuated BLP-vCA1 connection. Optogenetic disruption of BLP-vCA1 inputs abolishes the effects of LHF and impairs synaptic plasticity. By contrast, targeted BLP-vCA1 stimulation rescues the LHL-induced memory deficits and mimics the effects of LHF. BLP-vCA1 stimulation increases synaptic transmission and dendritic plasticity with the upregulation of CREB and intrasynaptic AMPA receptors in CA1. These findings indicate that opposite excitatory monosynaptic scaling of BLP-vCA1 controls LHF- and LHL-modulated spatial memory, revealing circuit-specific mechanisms linking emotions to memory.
WOS HeadingsScience & Technology
DOI10.1038/ncomms11935
WOS KeywordLONG-TERM POTENTIATION ; ALZHEIMERS-DISEASE ; HIPPOCAMPAL-FORMATION ; DEPRESSIVE SYMPTOMS ; DORSAL HIPPOCAMPUS ; IN-VIVO ; AMYGDALA ; STRESS ; FEAR ; PROJECTIONS
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000380746900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/9478
Collection磁共振应用研究部
Affiliation1.Huazhong Univ Sci & Technol, Dept Pathophysiol, Sch Basic Med, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Collaborat Innovat Ctr Brain Sci, Key Lab,Minist Educ China Neurol Disorders, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Shenzhen Key Lab Neuropsychiat Modulat, Shenzhen 518055, Peoples R China
4.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, CAS Ctr Excellence Brain Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
5.Chinese Acad Sci, Wuhan Inst Phys & Math, CAS Ctr Excellence Brain Sci, Wuhan 430071, Peoples R China
6.Huazhong Univ Sci & Technol, Sch Life Sci & Technol, Wuhan 430074, Peoples R China
7.Coinnovat Ctr Neuroregenerat, Nantong 226000, Peoples R China
Recommended Citation
GB/T 7714
Yang, Ying,Wang, Zhi-Hao,Jin, Sen,et al. Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory[J]. Nature Communications,2016,7.
APA Yang, Ying.,Wang, Zhi-Hao.,Jin, Sen.,Gao, Di.,Liu, Nan.,...&Wang, Jian-Zhi.(2016).Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory.Nature Communications,7.
MLA Yang, Ying,et al."Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory".Nature Communications 7(2016).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Ying]'s Articles
[Wang, Zhi-Hao]'s Articles
[Jin, Sen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Ying]'s Articles
[Wang, Zhi-Hao]'s Articles
[Jin, Sen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Ying]'s Articles
[Wang, Zhi-Hao]'s Articles
[Jin, Sen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.