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Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice
Wu, Junfang1; Yang, Liu2; Li, Shoufeng2; Huang, Ping2; Liu, Yong2; Wang, Yulan1,3; Tang, Huiru1,4
2016-07-01
Source PublicationJOURNAL OF PROTEOME RESEARCH
Volume15Issue:7Pages:2299-2308
SubtypeArticle
AbstractThere is increasing evidence that calorie restriction without malnutrition can extend longevity and delay the onset of age-associated disorders. Identifying the biochemical perturbations associated with different dietary habits would provide valuable insights into associations between metabolism and longevity. To reveal the effects of long-term dietary interventions on metabolic perturbations, we investigated serum and urinary metabolic changes induced by interactive high/low fat diet in combination with/without reduced caloric intake over a life span in mice using NMR-based metabonomics. We found that the high calorie dietary regime disturbed lipid metabolism, suppressed glycolysis and TCA cycles, stimulated oxidative stress, promoted nucleotide metabolism and gluconeogenesis, and perturbed gut microbiota host interactions. Such changes could be modified by long-term low calorie intake. Most importantly, we found that the calorie intake index exerts a dominant effect on metabolic perturbations irrespective of dietary regime. Our investigation provides a holistic view of the metabolic impact of long-term dietary interventions, which are important for detecting physiological changes and dietary effects on mammalian metabolism.
KeywordCalorie Restriction High Fat Diet Nmi Metabonomics Long-term Diet Interventions
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1021/acs.jproteome.6b00336
WOS KeywordHIGH-FAT-DIET ; INSULIN-RESISTANT MICE ; INDUCED OBESITY ; ENERGY RESTRICTION ; GUT MICROBIOTA ; BLOOD-PLASMA ; LIVER ; RAT ; NMR ; DISEASE
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemical Research Methods
WOS IDWOS:000379456400019
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/9457
Collection磁共振应用研究部
Affiliation1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
3.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
4.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev,Metabol & Syst, Shanghai 200433, Peoples R China
Recommended Citation
GB/T 7714
Wu, Junfang,Yang, Liu,Li, Shoufeng,et al. Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice[J]. JOURNAL OF PROTEOME RESEARCH,2016,15(7):2299-2308.
APA Wu, Junfang.,Yang, Liu.,Li, Shoufeng.,Huang, Ping.,Liu, Yong.,...&Tang, Huiru.(2016).Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice.JOURNAL OF PROTEOME RESEARCH,15(7),2299-2308.
MLA Wu, Junfang,et al."Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice".JOURNAL OF PROTEOME RESEARCH 15.7(2016):2299-2308.
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