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Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model
Xu, Shan1,2; Tian, Yuan2; Hu, Yili2; Zhang, Nijia1; Hu, Sheng3; Song, Dandan1; Wu, Zhengshun1; Wang, Yulan2,4; Cui, Yanfang1; Tang, Huiru5
2016-06-22
Source PublicationSCIENTIFIC REPORTS
Volume6
SubtypeArticle
AbstractThe effects of tumorigenesis and tumor growth on the non-involved organs remain poorly understood although many research efforts have already been made for understanding the metabolic phenotypes of various tumors. To better the situation, we systematically analyzed the metabolic phenotypes of multiple non-involved mouse organ tissues (heart, liver, spleen, lung and kidney) in an A549 lung cancer xenograft model at two different tumor-growth stages using the NMR-based metabonomics approaches. We found that tumor growth caused significant metabonomic changes in multiple non-involved organ tissues involving numerous metabolic pathways, including glycolysis, TCA cycle and metabolisms of amino acids, fatty acids, choline and nucleic acids. Amongst these, the common effects are enhanced glycolysis and nucleoside/nucleotide metabolisms. These findings provided essential biochemistry information about the effects of tumor growth on the non-involved organs.
WOS HeadingsScience & Technology
DOI10.1038/srep28057
WOS KeywordHIGH-FAT-DIET ; METABOLIC ALTERATIONS ; COLORECTAL-CANCER ; CHOLINE ; STATE ; MICE ; BIOSYNTHESIS ; SPECTROSCOPY ; PROGRESSION ; STATISTICS
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000378219600001
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/9407
Collection磁共振应用研究部
Affiliation1.Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
2.Univ Chinese Acad Sci, CAS Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China
3.Hubei Prov Canc Hosp, Dept Med Oncol, Wuhan 430079, Peoples R China
4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
5.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Key Lab Contemporary Anthropol,Metabon & Syst Bio, State Key Lab Genet Engn,Minist Educ,Sch Life Sci, Shanghai 200438, Peoples R China
Recommended Citation
GB/T 7714
Xu, Shan,Tian, Yuan,Hu, Yili,et al. Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model[J]. SCIENTIFIC REPORTS,2016,6.
APA Xu, Shan.,Tian, Yuan.,Hu, Yili.,Zhang, Nijia.,Hu, Sheng.,...&Tang, Huiru.(2016).Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model.SCIENTIFIC REPORTS,6.
MLA Xu, Shan,et al."Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model".SCIENTIFIC REPORTS 6(2016).
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