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NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING
Wu, H.1,2; Wang, X.2; Gao, Y.2; Lin, F.2; Song, T.1,2; Zou, Y.1,2; Xu, L.2; Lei, H.1,2
2016-05-13
Source PublicationNEUROSCIENCE
Volume322Pages:221-233
SubtypeArticle
AbstractBackground: Animal models of N-methyl-Daspartate receptor (NMDAR) antagonism have been widely used for schizophrenia research. Less is known whether these models are associated with macroscopic brain structural changes that resemble those in clinical schizophrenia. Methods: Magnetic resonance imaging (MRI) was used to measure brain structural changes in rats subjected to repeated administration of MK801 in a regimen (daily dose of 0.2 mg/kg for 14 consecutive days) known to be able to induce schizophrenia-like cognitive impairments. Results: Voxel-based morphometry (VBM) revealed significant gray matter (GM) atrophy in the hippocampus, ventral striatum (vStr) and cortex. Diffusion tensor imaging (DTI) demonstrated microstructural impairments in the corpus callosum (cc). Histopathological results corroborated the MRI findings. Limitations: Treatment-induced behavioral abnormalities were not measured such that correlation between the brain structural changes observed and schizophrenia-like behaviors could not be established. Conclusion: Chronic MK801 administration induces MRI-observable brain structural changes that are comparable to those observed in schizophrenia patients, supporting the notion that NMDAR hypofunction contributes to the pathology of schizophrenia. Imaging-derived brain structural changes in animal models of NMDAR antagonism may be useful measurements for studying the effects of treatments and interventions targeting schizophrenia. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
KeywordN-methyl-d-aspartate Receptor Schizophrenia Magnetic Resonance Imaging Rat Brain
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuroscience.2016.02.043
WOS KeywordDENDRITIC SPINE DENSITY ; 1ST-EPISODE SCHIZOPHRENIA ; CORPUS-CALLOSUM ; ANIMAL-MODEL ; GRAY-MATTER ; MOUSE MODEL ; ANTIPSYCHOTIC TREATMENT ; PREPULSE INHIBITION ; MRI ; ABNORMALITIES
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000372349800020
Citation statistics
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/9229
Collection磁共振基础研究部
Affiliation1.Huazhong Univ Sci & Technol, Hubei Bioinformat & Mol Imaging Key Lab, Britton Chance Ctr Biomed Photon, Coll Life Sci & Technol,Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Wu, H.,Wang, X.,Gao, Y.,et al. NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING[J]. NEUROSCIENCE,2016,322:221-233.
APA Wu, H..,Wang, X..,Gao, Y..,Lin, F..,Song, T..,...&Lei, H..(2016).NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING.NEUROSCIENCE,322,221-233.
MLA Wu, H.,et al."NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING".NEUROSCIENCE 322(2016):221-233.
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