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Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure
Wan, Qianfen1; He, Qinghua2; Deng, Xianbai3; Hao, Fuhua1; Tang, Huiru4; Wang, Yulan1,5
2016-01-27
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume64Issue:3Pages:714-723
SubtypeArticle
AbstractThe aim of this study is to thoroughly investigate the toxicity mechanism of mycotoxin T-2 toxin and to further understand the endogenous metabolic alterations induced by T-2 toxin. To achieve this, a nuclear magnetic resonance (NMR)-based metabonomics approach was used to analyze the metabolic alterations induced by a single intravenous injection of T-2 toxin (0.5 mg/kg of body weight) in piglets and broiler chickens. A range of metabolites in the plasma, liver, kidney, and spleen of broiler chickens and plasma of piglets was changed following T-2 toxin injection. For example, a rapid increase of amino acids together with a significant reduction of glucose and lipid occurred in the plasma of broiler chickens and piglets following T-2 toxin treatment. A significant accumulation of amino acids and modulated nucleotides were detected in the liver, kidney, and spleen of T-2 toxin-treated broiler chickens. These data indicated that T-2 toxin caused endogenous metabolic changes in multiple organs and perturbed various metabolic pathways, including energy, amino acid, and nucleotide metabolism, as well as oxidative stress. We also observed elevated levels of tryptophan in the T-2 toxin-treated broiler chickens, which may explain the reported neurotoxic effects of T-2 toxin. These findings provide important information on the toxicity of T-2 toxin and demonstrate the power of the NMR-based metabonomics approach in exploring the toxicity mechanism of xenobiotics.
KeywordT-2 Toxin Metabonomics Broiler Chicken Piglet
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1021/acs.jafc.5b05076
WOS KeywordEUKARYOTIC PROTEIN-SYNTHESIS ; DNA-DAMAGE ; ANALYTICAL REPRODUCIBILITY ; METABONOMIC ANALYSIS ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; LYMPHOID ORGANS ; GUINEA-PIGS ; TOXICITY ; RAT
Indexed BySCI
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000369044200021
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/9169
Collection磁共振应用研究部
Affiliation1.Univ Chinese Acad Sci, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, CAS,Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Hubei, Peoples R China
2.Shenzhen Univ, Dept Food Sci & Engn, Coll Chem & Environm Engn, Shenzhen 518060, Guangdong, Peoples R China
3.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China
4.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Metabol & Syst Biol Lab,Sch Life Sci, Shanghai 200433, Peoples R China
5.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Wan, Qianfen,He, Qinghua,Deng, Xianbai,et al. Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2016,64(3):714-723.
APA Wan, Qianfen,He, Qinghua,Deng, Xianbai,Hao, Fuhua,Tang, Huiru,&Wang, Yulan.(2016).Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,64(3),714-723.
MLA Wan, Qianfen,et al."Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64.3(2016):714-723.
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