APM OpenIR  > 磁共振应用研究部
Electrospun Polymer Blend Nanofibers for Tunable Drug Delivery: The Role of Transformative Phase Separation on Controlling the Release Rate
Tipduangta, Pratchaya1; Belton, Peter2; Fabian, Laszlo1; Wang, Li Ying3; Tang, Huiru3,4; Eddleston, Mark5; Qi, Sheng1
2016
Source PublicationMOLECULAR PHARMACEUTICS
Volume13Issue:1Pages:25-39
SubtypeArticle
AbstractElectrospun fibrous materials have a wide range of biomedical applications, many of them involving the use of polymers as matrices for incorporation of therapeutic agents. The use of polymer blends improves the tuneability of the physicochemical and mechanical properties of the drug loaded fibers. This also benefits the development of controlled drug release formulations, for which the release rate can be modified by altering the ratio of the polymers in the blend. However, to realize these benefits, a clear understanding of the phase behavior of the processed polymer blend is essential. This study reports an in depth investigation of the impact of the electrospinning process on the phase separation of a model partially miscible polymer blend, PVP K90 and HPMCAS, in comparison to other conventional solvent evaporation based processes including film casting and spin coating. The nanoscale stretching and ultrafast solvent removal of electrospinning lead to an enhanced apparent miscibility between the polymers, with the same blends showing micronscale phase separation when processed using film casting and spin coating. Nanoscale phase separation in electrospun blend fibers was confirmed in the dry state. Rapid, layered, macroscale phase separation of the two polymers occurred during the wetting of the fibers. This led to a biphasic drug release profile from the fibers, with a burst release from PVP-rich phases and a slower, more continuous release from HPMCAS-rich phases. It was noted that the model drug, paracetamol, had more favorable partitioning into the PVP-rich phase, which is likely to be a result of greater hydrogen bonding between PVP and paracetamol. This led to higher drug contents in the PVP-rich phases than the HPMCAS-rich phases. By alternating the proportions of the PVP and HPMCAS, the drug release rate can be modulated.
KeywordPhase Separation Polymer Blends Electrospinning Tunable Drug Release
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1021/acs.molpharmaceut.5b00359
WOS KeywordHOT-MELT EXTRUSION ; AMORPHOUS SOLID DISPERSIONS ; ACETATE SUCCINATE HPMCAS ; STATE NMR ; INDOMETHACIN ; SYSTEMS
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine ; Pharmacology & Pharmacy
WOS SubjectMedicine, Research & Experimental ; Pharmacology & Pharmacy
WOS IDWOS:000367866200003
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/9135
Collection磁共振应用研究部
Affiliation1.Univ E Anglia, Sch Pharm, Norwich NR4 7TJ, Norfolk, England
2.Univ E Anglia, Sch Chem, Norwich NR4 7TJ, Norfolk, England
3.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China
4.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev,Metabon & Syst, Shanghai 200433, Peoples R China
5.Univ Cambridge, Dept Chem, Cambridge CB2 1TN, England
Recommended Citation
GB/T 7714
Tipduangta, Pratchaya,Belton, Peter,Fabian, Laszlo,et al. Electrospun Polymer Blend Nanofibers for Tunable Drug Delivery: The Role of Transformative Phase Separation on Controlling the Release Rate[J]. MOLECULAR PHARMACEUTICS,2016,13(1):25-39.
APA Tipduangta, Pratchaya.,Belton, Peter.,Fabian, Laszlo.,Wang, Li Ying.,Tang, Huiru.,...&Qi, Sheng.(2016).Electrospun Polymer Blend Nanofibers for Tunable Drug Delivery: The Role of Transformative Phase Separation on Controlling the Release Rate.MOLECULAR PHARMACEUTICS,13(1),25-39.
MLA Tipduangta, Pratchaya,et al."Electrospun Polymer Blend Nanofibers for Tunable Drug Delivery: The Role of Transformative Phase Separation on Controlling the Release Rate".MOLECULAR PHARMACEUTICS 13.1(2016):25-39.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tipduangta, Pratchaya]'s Articles
[Belton, Peter]'s Articles
[Fabian, Laszlo]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tipduangta, Pratchaya]'s Articles
[Belton, Peter]'s Articles
[Fabian, Laszlo]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tipduangta, Pratchaya]'s Articles
[Belton, Peter]'s Articles
[Fabian, Laszlo]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.