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Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice
Singh, Vishal1; Chassaing, Benoit2; Zhang, Limin3,4,5,6; Yeoh, Beng San1; Xiao, Xia1; Kumar, Manish1; Baker, Mark T.2; Cai, Jingwei3; Walker, Rachel1; Borkowski, Kamil1; Harvatine, Kevin J.7; Singh, Nagendra8; Shearer, Gregory C.1; Ntambi, James M.9; Joe, Bina10; Patterson, Andrew D.3; Gewirtz, Andrew T.2; Vijay-Kumar, Matam1,11
2015-12-01
Source PublicationCELL METABOLISM
Volume22Issue:6Pages:983-996
SubtypeArticle
AbstractThe gut microbiota plays a key role in host metabolism. Toll-like receptor 5 (TLR5), a flagellin receptor, is required for gut microbiota homeostasis. Accordingly, TLR5-deficient (T5KO) mice are prone to develop microbiota-dependent metabolic syndrome. Here we observed that T5KO mice display elevated neutral lipids with a compositional increase of oleate [C18:1 (n9)] relative to wild-type littermates. Increased oleate contribution to hepatic lipids and liver SCD1 expression were both microbiota dependent. Analysis of short-chain fatty acids (SCFAs) and C-13-acetate label incorporation revealed elevated SCFA in ceca and hepatic portal blood and increased liver de novo lipogenesis in T5KO mice. Dietary SCFAs further aggravated metabolic syndrome in T5KO mice. Deletion of hepatic SCD1 not only prevented hepatic neutral lipid oleate enrichment but also ameliorated metabolic syndrome in T5KO mice. Collectively, these results underscore the key role of the gut microbiota-liver axis in the pathogenesis of metabolic diseases.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.cmet.2015.09.028
WOS KeywordCHAIN FATTY-ACIDS ; INDUCED INSULIN-RESISTANCE ; DIET-INDUCED OBESITY ; GUT MICROBIOTA ; INFLAMMATORY RESPONSES ; RECEPTOR GPR43 ; HOST ENERGY ; ESTERS ; LIPIDS ; CELLS
Indexed BySCI
Language英语
WOS Research AreaCell Biology ; Endocrinology & Metabolism
WOS SubjectCell Biology ; Endocrinology & Metabolism
WOS IDWOS:000365993100007
Citation statistics
Cited Times:64[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/9080
Collection磁共振应用研究部
Affiliation1.Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
2.Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
3.Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA
4.Chinese Acad Sci, Wuhan, Peoples R China
5.State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China
6.Natl Ctr Magnet Resonance, Wuhan, Peoples R China
7.Penn State Univ, Dept Anim Sci, University Pk, PA 16802 USA
8.Georgia Regents Univ, Biochem & Mol Biol, Augusta, GA 30912 USA
9.Univ Wisconsin, Dept Biochem & Nutr Sci, Madison, WI 53706 USA
10.Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, Toledo, OH 43614 USA
11.Penn State Univ, Dept Med, Med Ctr, Hershey, PA 17033 USA
Recommended Citation
GB/T 7714
Singh, Vishal,Chassaing, Benoit,Zhang, Limin,et al. Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice[J]. CELL METABOLISM,2015,22(6):983-996.
APA Singh, Vishal.,Chassaing, Benoit.,Zhang, Limin.,Yeoh, Beng San.,Xiao, Xia.,...&Vijay-Kumar, Matam.(2015).Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.CELL METABOLISM,22(6),983-996.
MLA Singh, Vishal,et al."Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice".CELL METABOLISM 22.6(2015):983-996.
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