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NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation
Feng, Yue1,2; Zhu, Hang1; Zhang, Xu1; Wang, Xuxia1; Xu, Fuqiang1; Tang, Huiru1; Ye, Chaohui1; Liu, Maili1
2015-10-20
Source PublicationPLOS ONE
Volume10Issue:10
SubtypeArticle
AbstractTo find out if content changes of the major functional cerebrum metabolites are interconnected and formed a network during the brain development, we obtained high-resolution magic-angle-spinning (HR-MAS) H-1 NMR spectra of cerebrum tissues of chick embryo aged from incubation day 10 to 20, and postnatal day 1, and analyzed the data with principal component analysis (PCA). Within the examined time window, 26 biological important molecules were identified and 12 of them changed their relative concentration significantly in a time-dependent manner. These metabolites are generally belonged to three categories, neurotransmitters, nutrition sources, and neuronal or glial markers. The relative concentration changes of the metabolites were interconnected among/between the categories, and, more interestingly, associated with the number and size of Nissl-positive neurons. These results provided valuable biochemical and neurochemical information to understand the development of the embryonic brain.
WOS HeadingsScience & Technology
DOI10.1371/journal.pone.0139948
WOS KeywordMAGNETIC-RESONANCE-SPECTROSCOPY ; PROTON MR SPECTROSCOPY ; HUMAN FETAL BRAIN ; FREE AMINO-ACIDS ; IN-VIVO ; RAT-BRAIN ; NEUROCHEMICAL PROFILE ; H-1-NMR SPECTROSCOPY ; H-1 ; METABOLITE
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000363028100018
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/9024
Collection磁共振基础研究部
Affiliation1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
2.Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
Recommended Citation
GB/T 7714
Feng, Yue,Zhu, Hang,Zhang, Xu,et al. NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation[J]. PLOS ONE,2015,10(10).
APA Feng, Yue.,Zhu, Hang.,Zhang, Xu.,Wang, Xuxia.,Xu, Fuqiang.,...&Liu, Maili.(2015).NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation.PLOS ONE,10(10).
MLA Feng, Yue,et al."NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation".PLOS ONE 10.10(2015).
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