APM OpenIR  > 2011年以前论文发表(包括2011年)
MRI of stroke using hyperpolarized Xe-129
Zhou, Xin1,2; Sun, Yanping2,3; Mazzanti, Mary2,3; Henninger, Nils4; Mansour, Joey2,3; Fisher, Marc4; Albert, Mitchell2,3
2011-02-01
Source PublicationNMR IN BIOMEDICINE
Volume24Issue:2Pages:170-175
SubtypeArticle
AbstractBecause there is no background signal from xenon in biological tissue, and because inhaled xenon is delivered to the brain by blood flow, we would expect a perfusion deficit, such as is seen in stroke, to reduce the xenon concentration in the region of the deficit. Thermal polarization yields negligible xenon signal relative to hyperpolarized xenon; therefore, hyperpolarized xenon can be used as a tracer of cerebral blood flow. Using a rat permanent right middle cerebral artery occlusion model, we demonstrated that hyperpolarized Xe-129 MRI is able to detect, in vivo, the hypoperfused area of focal cerebral ischemia, that is the ischemic core area of stroke. To the best of our knowledge, this is the first time that hyperpolarized Xe-129 MRI has been used to explore normal and abnormal cerebral perfusion. Our study shows a novel application of hyperpolarized Xe-129 MRI for imaging stroke, and further demonstrates its capacity to serve as a complementary tool to proton MRI for the study of the pathophysiology during brain hypoperfusion. Copyright (C) 2010 John Wiley & Sons, Ltd.
KeywordHyperpolarized Xe-129 Stroke Mri Rat Brain Infarct
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1002/nbm.1568
WOS KeywordNEPHROGENIC SYSTEMIC FIBROSIS ; CEREBRAL-BLOOD-FLOW ; ISCHEMIC LESION EVOLUTION ; ARTERY OCCLUSION ; RAT-BRAIN ; DIFFUSION ; NMR ; XENON ; GAS ; INFARCTION
Indexed BySCI
Language英语
WOS Research AreaBiophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS SubjectBiophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS IDWOS:000288209300007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/8235
Collection2011年以前论文发表(包括2011年)
Affiliation1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
2.Harvard Univ, Brigham & Womens Hosp, Dept Radiol, Sch Med, Boston, MA 02115 USA
3.Univ Massachusetts, Sch Med, Dept Radiol, Worcester, MA USA
4.Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA
Recommended Citation
GB/T 7714
Zhou, Xin,Sun, Yanping,Mazzanti, Mary,et al. MRI of stroke using hyperpolarized Xe-129[J]. NMR IN BIOMEDICINE,2011,24(2):170-175.
APA Zhou, Xin.,Sun, Yanping.,Mazzanti, Mary.,Henninger, Nils.,Mansour, Joey.,...&Albert, Mitchell.(2011).MRI of stroke using hyperpolarized Xe-129.NMR IN BIOMEDICINE,24(2),170-175.
MLA Zhou, Xin,et al."MRI of stroke using hyperpolarized Xe-129".NMR IN BIOMEDICINE 24.2(2011):170-175.
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