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An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T-1/T-2-weighted MR and CT multimodal imaging
Jin, Xiaoying1,2; Fang, Fang3; Liu, Jianhua4; Jiang, Chunhuan5; Han, Xueli4; Song, Zhongkai1; Chen, Jinxing1; Sun, Guoying1,2; Lei, Hao3; Lu, Lehui5
2015
Source PublicationNANOSCALE
Volume7Issue:38Pages:15680-15688
SubtypeArticle
AbstractLanthanide-based multimodal probes with high sensitivity, simple synthesis strategy, and good bio-compatibility promise new applications for clinical diagnosis. However, today's challenge is not only to develop high-performance multimodal probes for more accurate and reliable diagnosis, but also to understand the fate of these probes in vivo. In this context, a novel PEGylated Dy-doped NaGdF4 nanoprobe (PEG-NaGdF4:Dy) was designed and fabricated as a T-1/T-2-weighted MRI/CT imaging agent. This nanoprobe has a distinct longitudinal relaxivity (r(1) = 5.17 mM(-1) s(-1)), relatively high transverse relaxivity (r(2) = 10.64 mM(-1) s(-1)), and exhibits strong X-ray attenuation properties (44.70 HU L g(-1)) in vitro. Furthermore, T-1/T-2-weighted MRI/CT imaging in vivo confirmed that this PEG-NaGdF4:Dy nanoprobe could lead to a significant contrast enhancement effect on liver, spleen and kidney at 24 h post injection. The MTT assay, histological analysis, and biodistribution investigation demonstrated that this multifunctional nanoprobe possessed relatively low cytotoxicity, negligible tissue damage and could be completely excreted out of the body of mice as time prolonged. Therefore, the present PEG-NaGdF4:Dy nanoprobe has the potential for the development of multifunctional T-1/T-2-weighted MRI/CT imaging to provide more comprehensive and accurate diagnosis information.
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c5nr04065e
WOS KeywordRAY COMPUTED-TOMOGRAPHY ; UP-CONVERSION NANOPARTICLES ; IN-VIVO ; CONTRAST AGENTS ; MAGNETIC-RESONANCE ; MOLECULAR PROBES ; NANOCRYSTALS ; COMPLEXES ; THERAPY ; SIZE
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000361834100017
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/8175
Collection磁共振基础研究部
Affiliation1.Changchun Univ Technol, Sch Chem & Life Sci, Jilin Prov Key Lab Carbon Fiber Dev & Applicat, Changchun, Peoples R China
2.Changchun Univ Technol, Adv Inst Mat Sci, Changchun, Peoples R China
3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
4.Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Jilin, Peoples R China
5.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Jin, Xiaoying,Fang, Fang,Liu, Jianhua,et al. An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T-1/T-2-weighted MR and CT multimodal imaging[J]. NANOSCALE,2015,7(38):15680-15688.
APA Jin, Xiaoying.,Fang, Fang.,Liu, Jianhua.,Jiang, Chunhuan.,Han, Xueli.,...&Lu, Lehui.(2015).An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T-1/T-2-weighted MR and CT multimodal imaging.NANOSCALE,7(38),15680-15688.
MLA Jin, Xiaoying,et al."An ultrasmall and metabolizable PEGylated NaGdF4:Dy nanoprobe for high-performance T-1/T-2-weighted MR and CT multimodal imaging".NANOSCALE 7.38(2015):15680-15688.
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