WIPM OpenIR  > 2011年以前论文发表(包括2011年)
Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex
Yu, Chunshui1; Lin, Fuchun2; Zhao, Li3; Ye, Jing3; Qin, Wen1
2009-03-01
Source PublicationINTELLIGENCE
Volume37Issue:2Pages:174-180
SubtypeArticle
AbstractWhether patients with tuberous sclerosis complex (TSC) have brain normal-appearing white matter (NAWM) damage and whether such damage contributes to their intellectual disability were examined in 15 TSC patients and 15 gender- and age-matched healthy controls using diffusion tensor imaging (DTI). Histogram and region of interest (ROI) analyses of the mean diffusivity (MD) and fractional anisotropy (FA) were performed in the NAWM. Correlations between diffusion indices and the full-scale intelligence quotient (FSIQ) and normalized lesion volume were also investigated. Compared with controls, both histogram and ROI analyses showed significant (P<.05) increased MD and decreased FA in the NAWM of TSC patients. In TSC patients, some of the histogram- and ROI-derived diffusion indices of the NAWM were correlated with FSIQ (P<.01), but none of them were correlated with the normalized lesion volume. These findings indicate that TSC patients have occult damage in the NAWM, which might be an important neural basis for intellectual disability in these patients. (C) 2008 Elsevier Inc. All rights reserved.
KeywordTuberous Sclerosis Complex Intelligence Diffusion Tensor Magnetic Resonance Imaging Brain White Matter
WOS HeadingsSocial Sciences
DOI10.1016/j.intell.2008.06.001
WOS KeywordDIFFUSION TENSOR IMAGES ; MENTAL-RETARDATION ; INFANTILE SPASMS ; MULTIPLE-SCLEROSIS ; MRI FINDINGS ; BRAIN ; INTELLIGENCE ; CHILDREN ; EPILEPSY ; TRACT
Indexed BySSCI
Language英语
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000264911900007
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/8164
Collection2011年以前论文发表(包括2011年)
Affiliation1.Capital Med Univ, Dept Radiol, Xuanwu Hosp, Beijing 100053, Peoples R China
2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan, Peoples R China
3.Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China
Recommended Citation
GB/T 7714
Yu, Chunshui,Lin, Fuchun,Zhao, Li,et al. Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex[J]. INTELLIGENCE,2009,37(2):174-180.
APA Yu, Chunshui,Lin, Fuchun,Zhao, Li,Ye, Jing,&Qin, Wen.(2009).Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex.INTELLIGENCE,37(2),174-180.
MLA Yu, Chunshui,et al."Occult white matter damage contributes to intellectual disability in tuberous sclerosis complex".INTELLIGENCE 37.2(2009):174-180.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yu, Chunshui]'s Articles
[Lin, Fuchun]'s Articles
[Zhao, Li]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yu, Chunshui]'s Articles
[Lin, Fuchun]'s Articles
[Zhao, Li]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yu, Chunshui]'s Articles
[Lin, Fuchun]'s Articles
[Zhao, Li]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.