WIPM OpenIR  > 2011年以前论文发表(包括2011年)
Symbiotic gut microbes modulate human metabolic phenotypes
Li, Min1; Wang, Baohong2; Zhang, Menghui1; Rantalainen, Mattias6; Wang, Shengyue5; Zhou, Haokui1; Zhang, Yan1; Shen, Jian1; Pang, Xiaoyan1; Zhang, Meiling1; Wei, Hua1; Chen, Yu2; Lu, Haifeng2; Zuo, Jian2; Su, Mingming1; Qiu, Yunping1; Jia, Wei1; Xiao, Chaoni3,4; Smith, Leon M.6; Yang, Shengli1; Holmes, Elaine6; Tang, Huiru3; Zhao, Guoping5; Nicholson, Jeremy K.6; Li, Lanjuan2; Zhao, Liping1
2008-02-12
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume105Issue:6Pages:2117-2122
SubtypeArticle
AbstractHumans have evolved intimate symbiotic relationships with a consortium of gut microbes (microbiome) and individual variations in the microbiome influence host health, may be implicated in disease etiology, and affect drug metabolism, toxicity, and efficacy. However, the molecular basis of these microbe-host interactions and the roles of individual bacterial species are obscure. We now demonstrate a "transgenomic" approach to link gut microbiome and metabolic phenotype (metabotype) variation. We have used a combination of spectroscopic, microbiomic, and multivariate statistical tools to analyze fecal and urinary samples from seven Chinese individuals (sampled twice) and to model the microbial-host metabolic connectivities. At the species level, we found structural differences in the Chinese family gut microbiomes and those reported for American volunteers, which is consistent with population microbial cometabolic differences reported in epidemiological studies. We also introduce the concept of functional metagenomics, defined as "the characterization of key functional members of the microbiome that most influence host metabolism and hence health." For example, Faecalibacterium prausnitzii population variation is associated with modulation of eight urinary metabolites of diverse structure, indicating that this species is a highly functionally active member of the microbiome, influencing numerous host pathways. Other species were identified showing different and varied metabolic interactions. Our approach for understanding the dynamic basis of host-microbiome symbiosis provides a foundation for the development of functional metagenomics as a probe of systemic effects of drugs and diet that are of relevance to personal and public health care solutions.
KeywordCovariation Analysis Gut Microbiota Metabonomics Metabotype Metagenomics
WOS HeadingsScience & Technology
DOI10.1073/pnas.0712038105
WOS KeywordGRADIENT GEL-ELECTROPHORESIS ; 16S RIBOSOMAL-RNA ; SYSTEMS BIOLOGY ; CLONE LIBRARIES ; REVEALS ; SPECTROSCOPY ; POPULATIONS ; ECOLOGY ; OBESITY ; GENES
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000253261900062
Citation statistics
Cited Times:637[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/8040
Collection2011年以前论文发表(包括2011年)
Affiliation1.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ Key Lab Syst Biomed, Shanghai 200240, Peoples R China
2.Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diagnosis & Treatment Infect Dis, Hangzhou 310003, Peoples R China
3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
4.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Natl Human Genome Ctr, Shanghai MOST Key Lab Dis & Hlth Gen, Shanghai 201203, Peoples R China
6.Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Biomol & Med, London SW7 2AZ, England
Recommended Citation
GB/T 7714
Li, Min,Wang, Baohong,Zhang, Menghui,et al. Symbiotic gut microbes modulate human metabolic phenotypes[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2008,105(6):2117-2122.
APA Li, Min.,Wang, Baohong.,Zhang, Menghui.,Rantalainen, Mattias.,Wang, Shengyue.,...&Zhao, Liping.(2008).Symbiotic gut microbes modulate human metabolic phenotypes.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,105(6),2117-2122.
MLA Li, Min,et al."Symbiotic gut microbes modulate human metabolic phenotypes".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105.6(2008):2117-2122.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Min]'s Articles
[Wang, Baohong]'s Articles
[Zhang, Menghui]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Min]'s Articles
[Wang, Baohong]'s Articles
[Zhang, Menghui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Min]'s Articles
[Wang, Baohong]'s Articles
[Zhang, Menghui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.