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H-1 NMR investigation on interaction between ibuprofen and lipoproteins
Lan, Wenxian; Zhu, Hang; Zhou, Zhiming; Ye, Chaohui; Liu, Maili
2007-08-01
Source PublicationCHEMISTRY AND PHYSICS OF LIPIDS
Volume148Issue:2Pages:105-111
SubtypeArticle
AbstractA large number of studies indicate that oxidative modification of plasma lipoproteins, especially low-density lipoprotein (LDL), is a critical factor in initiation and progression of atherosclerosis. We have previously found that ibuprofen (IBP), a potential antioxidant drug to inhibit LDL oxidation, interacted with lipoproteins in intact human plasma. In the present study, we compare the binding affinities of IBP to LDL and HDL (high-density lipoprotein) by H-1 NMR spectroscopy. When IBP is added into the HDL and LDL samples, the -N+(CH3)(3) moieties of phosphatidylcholine (PC) and sphingomyelin (SM) in lipoprotein particles experience the chemical shift up-field drift. Intermolecular cross-peaks observed in NOESY spectra imply that there are direct interactions between ibuprofen and lipoproteins at both hydrophobic and hydrophilic (ionic) regions. These interactions are likely to be important in the solubility of ibuprofen into lipoprotein particles. Ibuprofen has higher impact on the PC and SM head group (-N+(CH3)(3)) and -(CH2)(n-) group in HDL than that in LDL. This could be explained by either IBP has higher binding affinity to HDL than to LDL, or IBP induces orientation of the phospholipid head group at the surface of the lipoprotein particles. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
KeywordNmr Lipoprotein Ibuprofen Antioxidant Interaction Affinity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.chemphyslip.2007.04.012
WOS KeywordLOW-DENSITY-LIPOPROTEIN ; NUCLEAR-MAGNETIC-RESONANCE ; CORONARY-HEART-DISEASE ; NMR-SPECTROSCOPY ; OXIDATIVE MODIFICATION ; SECONDARY PREVENTION ; BLOOD-PLASMA ; HUMAN SERUM ; VITAMIN-E ; PROTEIN
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000248433600008
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/7809
Collection2011年以前论文发表(包括2011年)
Affiliation1.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lan, Wenxian,Zhu, Hang,Zhou, Zhiming,et al. H-1 NMR investigation on interaction between ibuprofen and lipoproteins[J]. CHEMISTRY AND PHYSICS OF LIPIDS,2007,148(2):105-111.
APA Lan, Wenxian,Zhu, Hang,Zhou, Zhiming,Ye, Chaohui,&Liu, Maili.(2007).H-1 NMR investigation on interaction between ibuprofen and lipoproteins.CHEMISTRY AND PHYSICS OF LIPIDS,148(2),105-111.
MLA Lan, Wenxian,et al."H-1 NMR investigation on interaction between ibuprofen and lipoproteins".CHEMISTRY AND PHYSICS OF LIPIDS 148.2(2007):105-111.
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