APM OpenIR  > 2011年以前论文发表(包括2011年)
Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging
Wei, Li; Zhou, Gang; Li, Zhen; He, Li; Gao, Mingyuan; Tan, Jinquan; Lei, Hao
AbstractThe objective of this study was to examine the feasibility of detecting toxoplasmic brain lesions in a mouse model of cerebral toxoplasmosis by ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI). Toxoplasmosis encephalitis was induced in Kunming mice by intracerebral injection of Toxoplasma gondii tachyzoites. T-2- and T-2(*)-weighted MRI was performed 1, 3, 4, 5 and 6 days after infection before USPIO injection; immediately after USPIO injection; and 24 h later. A comparison of USPIO enhancement and Gd-DTPA enhancement was made in three toxoplasmic mice 4 days after infection. Hematoxylin and eosin staining and Prussian blue staining were performed to detect inflammatory reactions and presence of iron in and around the toxoplasmic brain lesions. Nonenhanced T-2-/T-2(*)-weighted imaging detected few abnormalities in the brain up to 5 days. Most mice developed prominent hydrocephalus at 6 days. Gd-DTPA-enhanced imaging showed prominent enhancement of the cerebral ventricles but revealed only few space-occupying lesions in the parenchyma. USPIO-enhanced T-2(*)-weighted imaging showed improved detection of toxoplasmic brain lesions that were invisible to nonenhanced T-2-/T-2(*)-weighted imaging and gadolinium-enhanced imaging. Most of the enhancing lesions showed nodular enhancement immediately after USPIO injection, some of which changed appearance 24 h later, having a ring enhancement at the outer rim. It can be concluded that USPIO enhancement of the toxoplasmic lesions may reflect blood-brain barrier impairment and/or inflammatory reactions associated with these lesions. USPIO-enhanced imaging may be used in combination with gadoliniumenhanced imaging to provide better characterization of toxoplasmic brain lesions and, potentially, improve the differential diagnosis of toxoplasmosis encephalitis. (c) 2007 Elsevier Inc. All rights reserved.
KeywordMagnetic Resonance Imaging Toxoplasmosis Encephalitis Uspio Mouse Brain
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
WOS Research AreaRadiology, Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000251488500013
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China
2.Wuhan Univ, Sch Med, Dept Immunol, Wuhan 430071, Peoples R China
3.Chinese Acad Sci, Inst Phys, State Key Lab Colloid Interface Sci & Chem Thermo, Beijing 100080, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wei, Li,Zhou, Gang,Li, Zhen,et al. Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging[J]. MAGNETIC RESONANCE IMAGING,2007,25(10):1442-1448.
APA Wei, Li.,Zhou, Gang.,Li, Zhen.,He, Li.,Gao, Mingyuan.,...&Lei, Hao.(2007).Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging.MAGNETIC RESONANCE IMAGING,25(10),1442-1448.
MLA Wei, Li,et al."Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging".MAGNETIC RESONANCE IMAGING 25.10(2007):1442-1448.
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