WIPM OpenIR  > 2011年以前论文发表(包括2011年)
Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives
Lu, ZB; Nie, GJ; Belton, PS; Tang, HR; Zhao, BL
2006-03-01
Source PublicationNEUROCHEMISTRY INTERNATIONAL
Volume48Issue:4Pages:263-274
SubtypeArticle
AbstractGallic acid and its derivatives are a group of naturally occurring polyphenol antioxidants which have recently been shown to have potential healthy effects. In order to understand the relationship between the structures of gallic acid derivatives, their antioxidant activities, and neuroprotective effects, we examined their free radical scavenging effects in liposome and anti-apoptotic activities in human SH-SY5Y cell induced by 6-hydrodopamine autooxidation. It was found that these polyphenol antioxidants exhibited different hydrophobicity and could cross through the liposome membrane to react with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical in a time and dose-dependent manner. At the same time, the structure-antioxidant activity relationship of gallic acid derivatives on scavenging DPPH free radical in the liposome was also analyzed based on theoretical investigations. Analysis of cell apoptosis, intracellular GSH levels, production of ROS and the influx of Ca2+ indicated that the protective effects of gallic acid derivatives in cell systems under oxidative stress depend on both their antioxidant capacities and hydrophobicity. However, the neuroprotective effects of gallic acid derivatives seem to depend more on their molecular polarities rather than antioxidant activities in the human SH-SY5Y cell line. In conclusion, these results reveal that compounds with high antioxidant activity and appropriate hydrophobicity are generally more effective in preventing the injury of oxidative stress in neurodegenerative diseases. (C) 2005 Elsevier Ltd. All rights reserved.
KeywordFree Radicals Antioxidant Esr Hydrophobicity Partition Coefficient Gallic Acid Oxidative Stress Reactive Oxygen Species Glutathione Apoptosis
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuint.2005.10.010
WOS KeywordRAPID COLORIMETRIC ASSAY ; OXIDATIVE STRESS ; PHENOLIC ANTIOXIDANTS ; PARKINSONS-DISEASE ; FREE-RADICALS ; CELL-DEATH ; SELECTIVE-INHIBITION ; NEUROBLASTOMA-CELLS ; INDUCED APOPTOSIS ; TEA CATECHINS
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences
WOS IDWOS:000235597000003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/4692
Collection2011年以前论文发表(包括2011年)
Affiliation1.Chinese Acad Sci, Inst Phys & Math, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China
2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Recognit Lab, Beijing 100101, Peoples R China
4.McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Dept Physiol, Montreal, PQ H3T 1E2, Canada
5.Univ E Anglia, Sch Chem Sci & Pharm, Norwich NR4 7TJ, Norfolk, England
6.Chinese Acad Sci, Grad Sch, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Lu, ZB,Nie, GJ,Belton, PS,et al. Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives[J]. NEUROCHEMISTRY INTERNATIONAL,2006,48(4):263-274.
APA Lu, ZB,Nie, GJ,Belton, PS,Tang, HR,&Zhao, BL.(2006).Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives.NEUROCHEMISTRY INTERNATIONAL,48(4),263-274.
MLA Lu, ZB,et al."Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives".NEUROCHEMISTRY INTERNATIONAL 48.4(2006):263-274.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lu, ZB]'s Articles
[Nie, GJ]'s Articles
[Belton, PS]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lu, ZB]'s Articles
[Nie, GJ]'s Articles
[Belton, PS]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lu, ZB]'s Articles
[Nie, GJ]'s Articles
[Belton, PS]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.