APM OpenIR
regionalmetabolicpatternsofabnormalpostoperativebehavioralperformanceinagedmiceassessedby1hnmrdynamicmappingmethod
Liu Taotao1; Li Zhengqian1; He Jindan1; Yang Ning1; Han Dengyang1; Li Yue1; Tian Xuebi2; Liu Huili3; Manyande Anne4; Xiang Hongbing2; Xu Fuqiang3; Wang Jie3; Guo Xiangyang1
2020
Source Publicationneurosciencebulletin
ISSN1673-7067
Volume36Issue:1Pages:25
AbstractAbnormal postoperative neurobehavioral performance (APNP) is a common phenomenon in the early postoperative period. The disturbed homeostatic status of metabolites in the brain after anesthesia and surgery might make a significant contribution to APNP. The dynamic changes of metabolites in different brain regions after anesthesia and surgery, as well as their potential association with APNP are still not well understood. Here, we used a battery of behavioral tests to assess the effects of laparotomy under isoflurane anesthesia in aged mice, and investigated the metabolites in 12 different sub-regions of the brain at different time points using proton nuclear magnetic resonance (~1H-NMR) spectroscopy. The abnormal neurobehavioral performance occurred at 6 h and/or 9 h, and recovered at 24 h after anesthesia/surgery. Compared with the control group, the altered metabolite of the model group at 6 h was aspartate (Asp), and the difference was mainly displayed in the cortex; while significant changes at 9 h occurred predominantly in the cortex and hippocampus, and the corresponding metabolites were Asp and glutamate (Glu). All changes returned to baseline at 24 h. The altered metabolic changes could have occurred as a result of the acute APNP, and the metabolites Asp and Glu in the cortex and hippocampus could provide preliminary evidence for understanding the APNP process.
KeywordAbnormal postoperative neurobehavioral performance ~1H-NMR Metabolite Aspartate Glutamate
DOI10.1007/s12264-019-00414-4
Language英语
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/22824
Collection中国科学院武汉物理与数学研究所
Affiliation1.北京大学
2.华中科技大学同济医学院
3.中国科学院武汉物理与数学研究所
4.西伦敦大学
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GB/T 7714
Liu Taotao,Li Zhengqian,He Jindan,et al. regionalmetabolicpatternsofabnormalpostoperativebehavioralperformanceinagedmiceassessedby1hnmrdynamicmappingmethod[J]. neurosciencebulletin,2020,36(1):25.
APA Liu Taotao.,Li Zhengqian.,He Jindan.,Yang Ning.,Han Dengyang.,...&Guo Xiangyang.(2020).regionalmetabolicpatternsofabnormalpostoperativebehavioralperformanceinagedmiceassessedby1hnmrdynamicmappingmethod.neurosciencebulletin,36(1),25.
MLA Liu Taotao,et al."regionalmetabolicpatternsofabnormalpostoperativebehavioralperformanceinagedmiceassessedby1hnmrdynamicmappingmethod".neurosciencebulletin 36.1(2020):25.
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