Liu Taotao1; Li Zhengqian1; He Jindan1; Yang Ning1; Han Dengyang1; Li Yue1; Tian Xuebi2; Liu Huili3; Manyande Anne4; Xiang Hongbing2; Xu Fuqiang3; Wang Jie3; Guo Xiangyang1
Source Publicationneurosciencebulletin
AbstractAbnormal postoperative neurobehavioral performance (APNP) is a common phenomenon in the early postoperative period. The disturbed homeostatic status of metabolites in the brain after anesthesia and surgery might make a significant contribution to APNP. The dynamic changes of metabolites in different brain regions after anesthesia and surgery, as well as their potential association with APNP are still not well understood. Here, we used a battery of behavioral tests to assess the effects of laparotomy under isoflurane anesthesia in aged mice, and investigated the metabolites in 12 different sub-regions of the brain at different time points using proton nuclear magnetic resonance (~1H-NMR) spectroscopy. The abnormal neurobehavioral performance occurred at 6 h and/or 9 h, and recovered at 24 h after anesthesia/surgery. Compared with the control group, the altered metabolite of the model group at 6 h was aspartate (Asp), and the difference was mainly displayed in the cortex; while significant changes at 9 h occurred predominantly in the cortex and hippocampus, and the corresponding metabolites were Asp and glutamate (Glu). All changes returned to baseline at 24 h. The altered metabolic changes could have occurred as a result of the acute APNP, and the metabolites Asp and Glu in the cortex and hippocampus could provide preliminary evidence for understanding the APNP process.
KeywordAbnormal postoperative neurobehavioral performance ~1H-NMR Metabolite Aspartate Glutamate
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
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GB/T 7714
Liu Taotao,Li Zhengqian,He Jindan,et al. regionalmetabolicpatternsofabnormalpostoperativebehavioralperformanceinagedmiceassessedby1hnmrdynamicmappingmethod[J]. neurosciencebulletin,2020,36(1):25.
APA Liu Taotao.,Li Zhengqian.,He Jindan.,Yang Ning.,Han Dengyang.,...&Guo Xiangyang.(2020).regionalmetabolicpatternsofabnormalpostoperativebehavioralperformanceinagedmiceassessedby1hnmrdynamicmappingmethod.neurosciencebulletin,36(1),25.
MLA Liu Taotao,et al."regionalmetabolicpatternsofabnormalpostoperativebehavioralperformanceinagedmiceassessedby1hnmrdynamicmappingmethod".neurosciencebulletin 36.1(2020):25.
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