APM OpenIR
Synthesis of Branched Monodisperse Oligoethylene Glycols and F-19 MRI-Traceable Biomaterials through Reductive Dimerization of Azides
Zhang, Jing1,2; Yuan, Yuan1,2; Li, Yu3; Yang, Hao1,2; Zhang, Huaibin1,2; Chen, Shizhen3; Zhou, Xin3; Yang, Zhigang1,2; Jiang, Zhong-Xing1,2
2020-05-15
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume85Issue:10Pages:6778-6787
AbstractMultifunctionalized and branched M-OEGs represent valuable PEGylation agents, linkers, and scaffolds in biomedicine. However, the tedious synthesis limited their availability and application. We herein present an azide reductive dimerization method for the convenient synthesis of aza-M-OEGs and derivatives, which provides easy access to a variety of multifunctionalized and branched M-OEGs in one step. With this method, hexa-arm M-OEGs with 54 symmetrical fluorines were synthesized in two steps as a water-soluble, self-assemble, F-19 MRI sensitive, and biocompatible dendritic biomaterial.
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS
DOI10.1021/acs.joc.0c00331
WOS KeywordPOLYETHYLENE-GLYCOL ; POLY(ETHYLENE GLYCOL) ; SECONDARY-AMINES ; PEGYLATION ; PEG ; THERAPEUTICS ; IMPACT ; WELL
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFA0704000] ; National Natural Science Foundation of China[81625011] ; Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-SLH018]
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, CAS ; Key Research Program of Frontier Sciences, CAS
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000535303300049
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/22693
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorYang, Zhigang; Jiang, Zhong-Xing
Affiliation1.Wuhan Univ, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Peoples R China
2.Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China
3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math,Innovat Acad Precis Measur, Wuhan 430071, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jing,Yuan, Yuan,Li, Yu,et al. Synthesis of Branched Monodisperse Oligoethylene Glycols and F-19 MRI-Traceable Biomaterials through Reductive Dimerization of Azides[J]. JOURNAL OF ORGANIC CHEMISTRY,2020,85(10):6778-6787.
APA Zhang, Jing.,Yuan, Yuan.,Li, Yu.,Yang, Hao.,Zhang, Huaibin.,...&Jiang, Zhong-Xing.(2020).Synthesis of Branched Monodisperse Oligoethylene Glycols and F-19 MRI-Traceable Biomaterials through Reductive Dimerization of Azides.JOURNAL OF ORGANIC CHEMISTRY,85(10),6778-6787.
MLA Zhang, Jing,et al."Synthesis of Branched Monodisperse Oligoethylene Glycols and F-19 MRI-Traceable Biomaterials through Reductive Dimerization of Azides".JOURNAL OF ORGANIC CHEMISTRY 85.10(2020):6778-6787.
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