APM OpenIR
Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice
Yuan, Peihong1,2; Dong, Manyuan2,3; Lei, Hehua2; Xu, Guangyong2,4; Chen, Gui2,3; Song, Yuchen2,3; Ma, Jianfeng4; Cheng, Liming1; Zhang, Limin2,5
2020-04-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume259Pages:9
AbstractEnvironmental exposure to 2,3,7,8-tetrachlorodibenzofuran (TCDF), one of typical persistent organic pollutants (POPs) produced from municipal waste combustion, exerts toxic effects on human healthy. In the current study, we mainly used targeted metabolomics combined with untargeted H-1 NMR-based metabolomics to investigate the effects of TCDF exposure on lipid homeostasis in mice. We found that TCDF exposure induced hepatic lipogenesis, the early-stage of non-alcoholic fatty liver disease, manifested by excessive lipids including triglycerides, fatty acids and lipotoxic ceramides accumulated in the liver together with elevated serum very low-density lipoprotein by activating the aryl hydrocarbon receptor (AHR) and its target genes such as Cyp1a1 and Cd36. We also found that TCDF exposure induced alteration of phospholipids and choline metabolites and endoplasmic reticulum (ER) markers in the liver of mice, indicating that disruption of host cell membrane structural integrity and ER stress leading to hepatic steatosis. In addition, complementary information was also obtained from histopathologic assessments and biological assays, strongly supporting toxic effects of TCDF. These results provide new evidence of TCDF toxicity associated with fatty liver disease and further our understanding of health effects of environmental pollutants exposure. (C) 2019 Elsevier Ltd. All rights reserved.
Keyword2,3,7,8-Tetrachlorodibenzofuran (TCDF) Metabolomics Hepatic steatosis The aryl hydrocarbon receptor
Funding OrganizationNational Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China
DOI10.1016/j.envpol.2019.113820
WOS KeywordLIVER FIBROSIS ; OBESITY ; DIOXIN ; RECEPTOR ; DIBENZOFURANS ; METABOLISM ; TISSUE ; PHOSPHATIDYLCHOLINE ; CHEMICALS ; CERAMIDE
Language英语
Funding ProjectNational Key Research and Development Program[2018YFE0110800] ; National Key Research and Development Program[2017YFC0909403] ; National Natural Science Foundation of China[21577169] ; National Natural Science Foundation of China[21635006]
Funding OrganizationNational Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program ; National Key Research and Development Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000528534600115
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/22626
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorCheng, Liming; Zhang, Limin
Affiliation1.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Lab Med, Wuhan, Peoples R China
2.Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Changzhou Univ, Sch Environm & Safety Engn, Changzhou 213164, Jiangsu, Peoples R China
5.Wuhan Natl Res Ctr Optoelect, Wuhan 430071, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Peihong,Dong, Manyuan,Lei, Hehua,et al. Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice[J]. ENVIRONMENTAL POLLUTION,2020,259:9.
APA Yuan, Peihong.,Dong, Manyuan.,Lei, Hehua.,Xu, Guangyong.,Chen, Gui.,...&Zhang, Limin.(2020).Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice.ENVIRONMENTAL POLLUTION,259,9.
MLA Yuan, Peihong,et al."Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice".ENVIRONMENTAL POLLUTION 259(2020):9.
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