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Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling
Zhao, Xiu-Ju1; Hao, Fuhua1; Huang, Chongyang1; Rantalainen, Mattias2; Lei, Hehua1; Tang, Huiru1; Wang, Yulan1
2012-09-01
Source PublicationJOURNAL OF PROTEOME RESEARCH
Volume11Issue:9Pages:4712-4721
SubtypeArticle
AbstractMequindox is used as an antibiotic drug in livestock; however, its toxicity remains largely unclear. Previously, we investigated metabolic responses of mice to mequindox exposure. In order to evaluate dependences of animal species in response to mequindox insult, we present the metabolic consequences of mequindox exposure in a rat model, by employing the combination of metabonomics and transcriptomics. Metabolic profiling of urine revealed that metabolic recovery is achieved for rats exposed to a low or moderate dose of mequindox, whereas high levels of mequindox exposure trigger liver dysfunction, causing no such recovery. We found that mequindox exposure causes suppression of the tricarboxylic acid cycle and stimulation of glycolysis, which is in contrast to a mouse model previously investigated. In addition, mequindox dosage induces promotion of beta-oxidation of fatty acids, Fumurute which was confirmed by elevated expressions of acox1, hsd17b2, and cpt1a in liver. Furthermore, altered levels of N-methylnicotinate, 1-methylnicotinamide, and glutathione disu fide highlighted the promotion of vitamin B3 antioxidative cycle in rats exposed to mequindox. Moreover, mequindox exposure altered levels of gut microbiotal related co-metabolites, suggesting a perturbation of the gut microflora of the host. Our work provides a comprehensive view of the toxicological effects of mequindox, which is important in the usage of mequindox in animal and human food safety.
KeywordMequindox Metabonomics Nmr Pattern Recognition Rat Transcriptomics
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1021/pr300533a
WOS KeywordCARNITINE PALMITOYLTRANSFERASE ; METABONOMIC INVESTIGATIONS ; HYDRAZINE TOXICITY ; SERINE DEHYDRATASE ; GUT MICROBIOTA ; MOUSE MODEL ; HUMAN LIVER ; MICE ; EXPRESSION ; SPECTROSCOPY
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemical Research Methods
WOS IDWOS:000308389900029
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/1681
Collection磁共振应用研究部
Affiliation1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
2.Univ Oxford, Dept Stat, Oxford OX1 3TG, England
Recommended Citation
GB/T 7714
Zhao, Xiu-Ju,Hao, Fuhua,Huang, Chongyang,et al. Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling[J]. JOURNAL OF PROTEOME RESEARCH,2012,11(9):4712-4721.
APA Zhao, Xiu-Ju.,Hao, Fuhua.,Huang, Chongyang.,Rantalainen, Mattias.,Lei, Hehua.,...&Wang, Yulan.(2012).Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling.JOURNAL OF PROTEOME RESEARCH,11(9),4712-4721.
MLA Zhao, Xiu-Ju,et al."Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling".JOURNAL OF PROTEOME RESEARCH 11.9(2012):4712-4721.
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