APM OpenIR
Stimulated phospholipid synthesis is key for hepatitis B virus replications
Huang, Qingxia1,2; Lei, Hehua1; Ding, Laifeng1,2; Wang, Yulan3
2019-09-10
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume9Pages:9
AbstractChronic hepatitis B Virus (HBV) infection has high morbidity, high pathogenicity and unclear pathogenesis. To elucidate the relationship between HBV replication and host phospholipid metabolites, we measured 10 classes of phospholipids in serum of HBV infected patients and cells using ultra performance liquid chromatograph-triple quadruple mass spectrometry. We found that the levels of phosphatidylcholine (PC), phosphatidylethanolamine, and lyso-phosphatidic acid were increased in HBsAg (+) serum of infected patients compared with HBsAg (-), while phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingomyelin were decreased, which were confirmed in an HBV infected HepG2.2.15 cell line. We further evaluated the enzyme levels of PC pathways and found that PCYT1A and LPP1 for PC synthesis were up-regulated after HBV infection. Moreover, HBV replication was inhibited when PCYT1A and LPP1 were inhibited. These results indicated that the PC synthesis in HBV infected host are regulated by PCYT1A and LPP1, which suggests that PCYT1A, LPP1 could be new potential targets for HBV treatment.
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China
DOI10.1038/s41598-019-49367-8
WOS KeywordHEPATOCELLULAR-CARCINOMA ; CELL ; ANTIGEN ; BIOSYNTHESIS ; EPIDEMIOLOGY ; INHIBITION ; ACTIVATION ; MECHANISMS ; PARTICLES ; RNAI
Language英语
Funding ProjectNational Key R&D Program of China[2017YFC0906800] ; National Science Foundation of China[21675169]
Funding OrganizationNational Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Science Foundation of China ; National Science Foundation of China
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000484986300003
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/14952
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorWang, Yulan
Affiliation1.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math,Key Lab Magnet Resonance B, Wuhan 430071, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore Phenome Ctr, 59 Nanyang Dr, Singapore, Singapore
Recommended Citation
GB/T 7714
Huang, Qingxia,Lei, Hehua,Ding, Laifeng,et al. Stimulated phospholipid synthesis is key for hepatitis B virus replications[J]. SCIENTIFIC REPORTS,2019,9:9.
APA Huang, Qingxia,Lei, Hehua,Ding, Laifeng,&Wang, Yulan.(2019).Stimulated phospholipid synthesis is key for hepatitis B virus replications.SCIENTIFIC REPORTS,9,9.
MLA Huang, Qingxia,et al."Stimulated phospholipid synthesis is key for hepatitis B virus replications".SCIENTIFIC REPORTS 9(2019):9.
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