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Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)
Tian, Yuan1,3; Gui, Wei1; Smith, Philip B.2; Koo, Imhoi1; Murray, Lain A.1; Cantorna, Margherita T.1; Perdew, Gary H.1; Patterson, Andrew D.1
2019-08-21
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume67Issue:33Pages:9286-9294
AbstractNatural aryl hydrocarbon (AHR) ligands have been identified in food and herbal medicines, and they may exhibit beneficial activity in humans. In this study, white button (WB) feeding significantly decreased AHR target gene expression in the small intestine of both conventional and germ-free mice. High-performance liquid chromatography (HPLC) fractionation and ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) combined with an AHR-responsive cell-based luciferase gene reporter assay were used to isolate and characterize benzothiazole (BT) derivatives and 6-methylisoquinoline (6-MIQ) as AHR modulators from WB mushrooms. The study showed dose-dependent changes of AHR transformation determined by the cell-based luciferase gene reporter assay and transcription of CYPIA1 in human Caco-2 cells by BT derivatives and 6-MIQ These findings suggested that WB mushroom contains new classes of natural AHR modulators and demonstrated HPLC fractionation and UHPLC-MS/MS combined with a cell-based luciferase gene reporter assay as a useful approach for isolation and characterization of the previously unidentifed AHR modulators from natural products.
Keywordwhite buttom mushroom aryl hydrocarbon ligand mass spectrometry
Funding OrganizationNational Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations
DOI10.1021/acs.jafc.9b03212
WOS KeywordMASS SPECTROMETRY ; DERIVATIVES ; AHR ; BENZOTHIAZOLE ; QUINOLINE ; LIGANDS ; INHIBITION ; METABOLISM ; FLAVONOIDS ; OBESITY
Language英语
Funding ProjectNational Institutes of Health[ES028288] ; National Institutes of Health[ES026684] ; National Institutes of Health[ES028244] ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations[PEN04607] ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations[1009993]
Funding OrganizationNational Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; National Institutes of Health ; National Institutes of Health ; Pennsylvania Department of Health ; Pennsylvania Department of Health ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations ; United States Department of Agriculture (USDA) National Institute of Food and Federal Appropriations
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000482546200017
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/14906
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorPatterson, Andrew D.
Affiliation1.Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA
2.Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA
3.Univ Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, CAS,Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Ph, Wuhan 430071, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Tian, Yuan,Gui, Wei,Smith, Philip B.,et al. Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(33):9286-9294.
APA Tian, Yuan.,Gui, Wei.,Smith, Philip B..,Koo, Imhoi.,Murray, Lain A..,...&Patterson, Andrew D..(2019).Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(33),9286-9294.
MLA Tian, Yuan,et al."Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.33(2019):9286-9294.
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