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Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production
Zhou, Dengyuan1,2,3; Jia, Fan4; Li, Qiuyan1,2,3; Zhang, Luping1,2,3; Chen, Zheng1,2,3; Zhao, Zikai1,2,3; Cui, Min1,2,3; Song, Yunfeng1,2,3; Chen, Huanchun1,2,3; Cao, Shengbo1,2,3; Ye, Jing1,2,3
2018-12-01
Source PublicationVIROLOGICA SINICA
ISSN1674-0769
Volume33Issue:6Pages:515-523
AbstractJapanese encephalitis virus (JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1, a 52-amino acid C-terminal extension of NS1, is generated with a -1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses. Previous studies demonstrated that NS1 plays a vital role in virulence, but the mechanism is unclear. In this study, an NS1 defected (rG66A) virus was generated. We found that rG66A virus was less virulent than its parent virus (pSA14) in wild-type mice. However, similar mortality caused by the two viruses was observed in an IFNAR knockout mouse model. Moreover, we found that rG66A virus induced a greater type I interferon (IFN) response than that by pSA14, and JEV NS1 significantly inhibited the production of IFN- and IFN-stimulated genes. Taken together, our results reveal that NS1 plays a vital role in blocking type I IFN production to help JEV evade antiviral immunity and benefit viral replication.
KeywordJapanese encephalitis virus (JEV) NS1 Type I interferon (IFN-I) Immune evasion
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities
DOI10.1007/s12250-018-0067-5
WOS KeywordWEST-NILE ; FLAVIVIRUSES ; PATHOGENESIS ; CONTRIBUTES ; MUTATION ; NS2A
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFD0500407] ; National Natural Science Foundation of China[31502065] ; National Natural Science Foundation of China[31572517] ; Fundamental Research Funds for the Central Universities[2013PY051] ; Fundamental Research Funds for the Central Universities[2662016Q003] ; Fundamental Research Funds for the Central Universities[2662015PY083]
Funding OrganizationNational Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities
WOS Research AreaVirology
WOS SubjectVirology
WOS IDWOS:000455958600007
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/14127
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorYe, Jing
Affiliation1.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China
2.Huazhong Agr Univ, Coll Vet Med, Key Lab Prevent Vet Med Hubei Prov, Wuhan 430070, Hubei, Peoples R China
3.Huazhong Agr Univ, Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Hubei, Peoples R China
4.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430070, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Dengyuan,Jia, Fan,Li, Qiuyan,et al. Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production[J]. VIROLOGICA SINICA,2018,33(6):515-523.
APA Zhou, Dengyuan.,Jia, Fan.,Li, Qiuyan.,Zhang, Luping.,Chen, Zheng.,...&Ye, Jing.(2018).Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production.VIROLOGICA SINICA,33(6),515-523.
MLA Zhou, Dengyuan,et al."Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production".VIROLOGICA SINICA 33.6(2018):515-523.
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