APM OpenIR
Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets
Wang, Meng1; Wang, Jiqian1; Zhou, Peng1; Deng, Jing2; Zhao, Yurong1; Sun, Yawei1; Yang, Wei1; Wang, Dong1; Li, Zongyi3; Hu, Xuzhi3; King, Stephen M.4; Rogers, Sarah E.4; Cox, Henry3; Waigh, Thomas A.3; Yang, Jun2; Lu, Jian Ren3; Xu, Hai1
2018-11-30
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume9Pages:11
AbstractPeptide self-assembly is a hierarchical process, often starting with the formation of a-helices, beta-sheets or beta-hairpins. However, how the secondary structures undergo further assembly to form higher-order architectures remains largely unexplored. The polar zipper originally proposed by Perutz is formed between neighboring beta-strands of poly-glutamine via their side-chain hydrogen bonding and helps to stabilize the sheet. By rational design of short amphiphilic peptides and their self-assembly, here we demonstrate the formation of polar zippers between neighboring beta-sheets rather than between beta-strands within a sheet, which in turn intermesh the beta-sheets into wide and flat ribbons. Such a super-secondary structural template based on well-defined hydrogen bonds could offer an agile route for the construction of distinctive nanostructures and nanomaterials beyond beta-sheets.
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project
DOI10.1038/s41467-018-07583-2
WOS KeywordAMYLOID FIBRILS ; AMINO-ACIDS ; NANOSTRUCTURES ; POLYMORPHISM ; AMPHIPHILES ; HANDEDNESS ; NANOTUBES ; HYDROGELS ; MODEL ; NMR
Language英语
Funding ProjectNational Natural Science Foundation of China[21673293] ; National Natural Science Foundation of China[21573287] ; National Natural Science Foundation of China[21425523] ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK[EP/F062966/1] ; Innovate UK[KTP008143] ; NSF[DMR-0520547] ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project[654000]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000451742700023
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/13546
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorWang, Jiqian; Lu, Jian Ren; Xu, Hai
Affiliation1.China Univ Petr East China, Coll Chem Engn, Ctr Bioengn & Biotechnol, 66 Changjiang West Rd, Qingdao 266580, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst,Natl Ctr Magne, Wuhan 430071, Hubei, Peoples R China
3.Univ Manchester, Sch Phys & Astron, Biol Phys Grp, Manchester M13 9PL, Lancs, England
4.STFC Rutherford Appleton Lab, ISIS Pulsed Neutron Source, Didcot OX11 0QX, Oxon, England
Recommended Citation
GB/T 7714
Wang, Meng,Wang, Jiqian,Zhou, Peng,et al. Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets[J]. NATURE COMMUNICATIONS,2018,9:11.
APA Wang, Meng.,Wang, Jiqian.,Zhou, Peng.,Deng, Jing.,Zhao, Yurong.,...&Xu, Hai.(2018).Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets.NATURE COMMUNICATIONS,9,11.
MLA Wang, Meng,et al."Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets".NATURE COMMUNICATIONS 9(2018):11.
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