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Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction
Zhang, Zeting1; Jiang, Xin1,2; Xu, Danrui1,2; Zheng, Wenwen1,2; Liu, Maili1; Li, Conggang1
2018-09-01
Source PublicationBIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
ISSN0005-2736
Volume1860Issue:9Pages:1848-1853
SubtypeArticle
Abstractalpha-Synuclein is involved in Parkinson's disease, and its interaction with cell membrane is vital to its pathological and physiological functions. We have shown that Ca2+ can regulate alpha-synuclein membrane interaction, but the physiological role of Ca2+ in modulating alpha-synuclein membrane interaction is still unexplored. Based on the previous findings that alpha-synuclein inhibits membrane fusion and its inhibitory effect is highly related to its membrane binding, here we employed solution state Nuclear Magnetic Resonance (NMR) spectroscopy and the ensemble fluorescence fusion assay to show that Ca2+ can modulate the inhibitory effect of alpha-synuclein on SNARE-mediated membrane fusion through disrupting alpha-synuclein membrane interaction, resulting in acceleration of SNARE-mediated membrane fusion. These results suggest a modulatory effect of Ca2+ on membrane mediated normal function of alpha-synuclein, which of importance for the study of the Parkinson's disease.
KeywordAlpha-synuclein Ca2++ Nmr Spectroscopy Membrane Binding Snare-mediated Membrane Fusion
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284)
DOI10.1016/j.bbamem.2018.03.025
WOS KeywordSOLUTION NMR-SPECTROSCOPY ; NEUROTRANSMITTER RELEASE ; VESICLE DOCKING ; BINDING ; PROTEIN ; FUSION ; AGGREGATION ; EXOCYTOSIS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284) ; National Natural Science Foundation of China(21203243 ; National Natural Science Foundation of China(21203243 ; 21673284) ; 21673284)
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000442333600025
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/13057
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorLi, Conggang
Affiliation1.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Hubei, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zeting,Jiang, Xin,Xu, Danrui,et al. Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2018,1860(9):1848-1853.
APA Zhang, Zeting,Jiang, Xin,Xu, Danrui,Zheng, Wenwen,Liu, Maili,&Li, Conggang.(2018).Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1860(9),1848-1853.
MLA Zhang, Zeting,et al."Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1860.9(2018):1848-1853.
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