APM OpenIR
The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition
Wang, Shao-Ru1; Wang, Jia-Qi1; Xu, Guo-Hua2; Wei, Lai1; Fu, Bo-Shi1; Wu, Ling-Yu1; Song, Yan-Yan1; Yang, Xi-Ran3; Li, Conggang2; Liu, Si-Min3; Zhou, Xiang1
2018-07-01
Source PublicationADVANCED SCIENCE
ISSN2198-3844
Volume5Issue:7
SubtypeArticle
AbstractAs a left-handed helical structure, Z-DNA is biologically active and it may be correlated with transcription and genome stability. Until recently, it remained a significant challenge to control the B/Z-DNA transition under physiological conditions. The current study represents the first to reversibly control B/Z-DNA transition using cucurbit[7]uril-based supramolecular approach. It is demonstrated that cucurbit[7]uril can encapsulate the central butanediamine moiety [HN(CH2)(4)NH] and reverses Z-DNA caused by spermine back to B-DNA. The subsequent treatment with 1-adamantanamine disassembles the cucurbit[7]uril/spermine complex and readily induces reconversion of B- into Z-DNA. The DNA conformational change is unequivocally demonstrated using different independent methods. Direct evidence for supramolecular interactions involved in DNA conformational changes is further provided. These findings can therefore open a new route to control DNA helical structure in a reversible way.
KeywordCucurbit[7]Uril Reversible B/z-dna Transitions Spermine Supramolecular Chemistry
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Funding OrganizationNational Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143)
DOI10.1002/advs.201800231
WOS KeywordHANDED Z-DNA ; BIOTIN-AVIDIN PAIR ; B-DNA ; CIRCULAR-DICHROISM ; BINDING ; PROTEIN ; SALT ; PORPHYRIN ; EXPRESSION ; AFFINITY
Indexed BySCI
Language英语
Funding OrganizationNational Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143) ; National Science Foundation of China(21432008 ; National Science Foundation of China(21432008 ; 21722803 ; 21722803 ; 21721005 ; 21721005 ; 21672165 ; 21672165 ; 81373256 ; 81373256 ; 21372182 ; 21372182 ; 21472143) ; 21472143)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000439842100010
PublisherWILEY
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/13035
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorWang, Shao-Ru; Zhou, Xiang
Affiliation1.Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Hubei, Peoples R China
3.Wuhan Univ Sci & Technol, Coll Chem Engn & Technol, Wuhan 430081, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shao-Ru,Wang, Jia-Qi,Xu, Guo-Hua,et al. The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition[J]. ADVANCED SCIENCE,2018,5(7).
APA Wang, Shao-Ru.,Wang, Jia-Qi.,Xu, Guo-Hua.,Wei, Lai.,Fu, Bo-Shi.,...&Zhou, Xiang.(2018).The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition.ADVANCED SCIENCE,5(7).
MLA Wang, Shao-Ru,et al."The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition".ADVANCED SCIENCE 5.7(2018).
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