APM OpenIR
Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis
Tian, Yuan1,2,3; Nichols, Robert G.2; Cai, Jingwei2; Patterson, Andrew D.1,2; Cantorna, Margherita T.1
2018-04-01
Source PublicationJOURNAL OF NUTRITIONAL BIOCHEMISTRY
ISSN0955-2863
Volume54Pages:28-34
SubtypeArticle
AbstractVitamin A deficiency (A) is a worldwide public health problem. To better understand how vitamin A status influences gut microbiota and host metabolism, we systematically analyzed urine, cecum, serum and liver samples from vitamin A sufficient (A+) and deficient (A) mice using H-1 NMR-based metabolomics, quantitative (q)PCR and 16S rRNA gene sequencing coupled with multivariate data analysis. The microbiota in the cecum of A mice showed compositional as well as functional shifts compared to the microbiota from A+ mice. Targeted 1H NMR analyses revealed significant changes in microbial metabolite concentrations including higher butyrate and hippurate and decreased acetate and 4-hydroxyphenylacetate in A+ relative to A mice. Bacterial butyrate producing genes including butyryl-CoA:acetate CoA-transferase and butyrate kinase were significantly higher in bacteria from A+ versus bacteria from A mice. A mice had disturbances in multiple metabolic pathways including alterations in energy (hyperglycemia, glycogenesis, TCA cycle and lipoprotein biosynthesis), amino acid and nucleic acid metabolism. A mice had hyperglycemia, liver dysfunction, changes in bacterial metabolism and altered gut microbial communities. Moreover, integrative analyses indicated a strong correlation between gut microbiota and host energy metabolism pathways in the liver. Vitamin A regulates host and bacterial metabolism, and the result includes alterations in energy homeostasis. (C) 2017 Elsevier Inc. All rights reserved.
KeywordVitamin a Microbiota Short-chain Fatty Acids Diabetes Metabolomics
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationAmerican Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972)
DOI10.1016/j.jnutbio.2017.10.011
WOS KeywordREGULATORY T-CELLS ; CHAIN FATTY-ACIDS ; RETINOIC ACID ; H-1-NMR SPECTROSCOPY ; OBESITY ; DISEASE ; DIET ; TIME ; DIFFERENTIATION ; COMMUNITIES
Indexed BySCI
Language英语
Funding OrganizationAmerican Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972) ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56A1114972) ; National Institutes of Health(R56A1114972)
WOS Research AreaBiochemistry & Molecular Biology ; Nutrition & Dietetics
WOS SubjectBiochemistry & Molecular Biology ; Nutrition & Dietetics
WOS IDWOS:000429504900004
PublisherELSEVIER SCIENCE INC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/12939
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorCantorna, Margherita T.
Affiliation1.Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA
2.Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
3.Univ Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, CAS Key Lab Magnet Resonance Biol Syst,State Key, Wuhan 430071, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Tian, Yuan,Nichols, Robert G.,Cai, Jingwei,et al. Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2018,54:28-34.
APA Tian, Yuan,Nichols, Robert G.,Cai, Jingwei,Patterson, Andrew D.,&Cantorna, Margherita T..(2018).Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,54,28-34.
MLA Tian, Yuan,et al."Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 54(2018):28-34.
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