APM OpenIR
Stress Accelerates Defensive Responses to Looming in Mice and Involves a Locus Coeruleus-Superior Colliculus Projection
Li, Lei1,2; Feng, Xiaolong1,2; Zhou, Zheng1,2,3; Zhang, Huiqi1,2; Shi, Qianqian1,2; Lei, Zhuogui1,2; Shen, Peilei1,2,3; Yang, Qingning1,2; Zhao, Binghao1,2,3; Chen, Shuran1,2,3; Li, Lin1,2; Zhang, Yulin1,2,3; Wen, Pengjie4,5; Lu, Zhonghua1,2; Li, Xiang1,2; Xu, Fuqiang4,5; Wang, Liping1,2
2018-03-19
Source PublicationCURRENT BIOLOGY
ISSN0960-9822
Volume28Issue:6Pages:859-+
SubtypeArticle
AbstractDefensive responses to threatening stimuli are crucial to the survival of species. While expression of these responses is considered to be instinctive and unconditional, their magnitude may be affected by environmental and internal factors. The neural circuits underlying this modulation are still largely unknown. In mice, looming-evoked defensive responses are mediated by the superior colliculus (SC), a subcortical sensorimotor integration center. We found that repeated stress caused an anxiety-like state in mice and accelerated defensive responses to looming. Stress also induced c-fos activation in locus coeruleus (LC) tyrosine hydroxylase (TH)(+) neurons and modified adrenergic receptor expression in SC, suggesting a possible Th::LC-SC projection that may be involved in the accelerated defensive responses. Indeed, both anterograde and retrograde neural tracing confirmed the anatomical Th:: LC-SC projection and that the SC-projecting TH+ neurons in LC were activated by repeated stress. Optogenetic stimulation of either LC TH+ neurons or the Th:: LC-SC fibers also caused anxiety-like behaviors and accelerated defensive responses to looming. Meanwhile, chemogenetic inhibition of LC TH+ neurons and the infusion of an adrenergic receptor antagonist in SC abolished the enhanced looming defensive responses after repeated stress, confirming the necessity of this pathway. These findings suggest that the Th:: LC-SC pathway plays a key role in the sophisticated adjustments of defensive behaviors induced by changes in physiological states.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China (NSFC)(31630031 ; National Natural Science Foundation of China (NSFC)(31630031 ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; NSFC 81425010 ; NSFC 81425010 ; KQJSCX20160301144002 ; KQJSCX20160301144002 ; NSFC 31471109 ; NSFC 31471109 ; JCYJ20140417113430710 ; JCYJ20140417113430710 ; NSFC 31500861) ; NSFC 31500861) ; JCYJ20151030140325151 ; JCYJ20151030140325151 ; JSGG20160429184327274 ; JSGG20160429184327274 ; JCYJ20150630114942262 ; JCYJ20150630114942262 ; JCYJ20150401150223647) ; JCYJ20150401150223647) ; National Natural Science Foundation of China (NSFC)(31630031 ; National Natural Science Foundation of China (NSFC)(31630031 ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; NSFC 81425010 ; NSFC 81425010 ; KQJSCX20160301144002 ; KQJSCX20160301144002 ; NSFC 31471109 ; NSFC 31471109 ; JCYJ20140417113430710 ; JCYJ20140417113430710 ; NSFC 31500861) ; NSFC 31500861) ; JCYJ20151030140325151 ; JCYJ20151030140325151 ; JSGG20160429184327274 ; JSGG20160429184327274 ; JCYJ20150630114942262 ; JCYJ20150630114942262 ; JCYJ20150401150223647) ; JCYJ20150401150223647) ; National Natural Science Foundation of China (NSFC)(31630031 ; National Natural Science Foundation of China (NSFC)(31630031 ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; NSFC 81425010 ; NSFC 81425010 ; KQJSCX20160301144002 ; KQJSCX20160301144002 ; NSFC 31471109 ; NSFC 31471109 ; JCYJ20140417113430710 ; JCYJ20140417113430710 ; NSFC 31500861) ; NSFC 31500861) ; JCYJ20151030140325151 ; JCYJ20151030140325151 ; JSGG20160429184327274 ; JSGG20160429184327274 ; JCYJ20150630114942262 ; JCYJ20150630114942262 ; JCYJ20150401150223647) ; JCYJ20150401150223647) ; National Natural Science Foundation of China (NSFC)(31630031 ; National Natural Science Foundation of China (NSFC)(31630031 ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; NSFC 81425010 ; NSFC 81425010 ; KQJSCX20160301144002 ; KQJSCX20160301144002 ; NSFC 31471109 ; NSFC 31471109 ; JCYJ20140417113430710 ; JCYJ20140417113430710 ; NSFC 31500861) ; NSFC 31500861) ; JCYJ20151030140325151 ; JCYJ20151030140325151 ; JSGG20160429184327274 ; JSGG20160429184327274 ; JCYJ20150630114942262 ; JCYJ20150630114942262 ; JCYJ20150401150223647) ; JCYJ20150401150223647)
DOI10.1016/j.cub.2018.02.005
WOS KeywordNORADRENERGIC SYSTEM ; NEURONAL CIRCUITS ; NEURAL CIRCUITS ; VISUAL PATHWAY ; FEAR RESPONSES ; MODULATION ; ANXIETY ; MEMORY ; ENHANCEMENT ; ACTIVATION
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China (NSFC)(31630031 ; National Natural Science Foundation of China (NSFC)(31630031 ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; NSFC 81425010 ; NSFC 81425010 ; KQJSCX20160301144002 ; KQJSCX20160301144002 ; NSFC 31471109 ; NSFC 31471109 ; JCYJ20140417113430710 ; JCYJ20140417113430710 ; NSFC 31500861) ; NSFC 31500861) ; JCYJ20151030140325151 ; JCYJ20151030140325151 ; JSGG20160429184327274 ; JSGG20160429184327274 ; JCYJ20150630114942262 ; JCYJ20150630114942262 ; JCYJ20150401150223647) ; JCYJ20150401150223647) ; National Natural Science Foundation of China (NSFC)(31630031 ; National Natural Science Foundation of China (NSFC)(31630031 ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; NSFC 81425010 ; NSFC 81425010 ; KQJSCX20160301144002 ; KQJSCX20160301144002 ; NSFC 31471109 ; NSFC 31471109 ; JCYJ20140417113430710 ; JCYJ20140417113430710 ; NSFC 31500861) ; NSFC 31500861) ; JCYJ20151030140325151 ; JCYJ20151030140325151 ; JSGG20160429184327274 ; JSGG20160429184327274 ; JCYJ20150630114942262 ; JCYJ20150630114942262 ; JCYJ20150401150223647) ; JCYJ20150401150223647) ; National Natural Science Foundation of China (NSFC)(31630031 ; National Natural Science Foundation of China (NSFC)(31630031 ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; NSFC 81425010 ; NSFC 81425010 ; KQJSCX20160301144002 ; KQJSCX20160301144002 ; NSFC 31471109 ; NSFC 31471109 ; JCYJ20140417113430710 ; JCYJ20140417113430710 ; NSFC 31500861) ; NSFC 31500861) ; JCYJ20151030140325151 ; JCYJ20151030140325151 ; JSGG20160429184327274 ; JSGG20160429184327274 ; JCYJ20150630114942262 ; JCYJ20150630114942262 ; JCYJ20150401150223647) ; JCYJ20150401150223647) ; National Natural Science Foundation of China (NSFC)(31630031 ; National Natural Science Foundation of China (NSFC)(31630031 ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; International Partnership Program of Chinese Academy of Sciences(172644KYS820170004) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; External Cooperation Program of the Chinese Academy of Sciences(GJHZ1508) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017) ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen governmental grant(JCYJ20150529143500959 ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Shenzhen Discipline Construction Project for Neurobiology DRCSM([2016]1379) ; Ten Thousand Talent Program ; Ten Thousand Talent Program ; NSFC 81425010 ; NSFC 81425010 ; KQJSCX20160301144002 ; KQJSCX20160301144002 ; NSFC 31471109 ; NSFC 31471109 ; JCYJ20140417113430710 ; JCYJ20140417113430710 ; NSFC 31500861) ; NSFC 31500861) ; JCYJ20151030140325151 ; JCYJ20151030140325151 ; JSGG20160429184327274 ; JSGG20160429184327274 ; JCYJ20150630114942262 ; JCYJ20150630114942262 ; JCYJ20150401150223647) ; JCYJ20150401150223647)
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000427701500019
PublisherCELL PRESS
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/12887
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorWang, Liping
Affiliation1.Chinese Acad Sci, Shenzhen Key Lab Neuropsychiat Modulat, Shenzhen 518055, Peoples R China
2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Brain Cognit & Brain Dis Inst BCBDI,Shenzhen Inst, Collaborat Innovat Ctr Brain Sci,Guangdong Prov K, Shenzhen 518055, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, Ctr Brain Sci, Wuhan 430071, Peoples R China
5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
Recommended Citation
GB/T 7714
Li, Lei,Feng, Xiaolong,Zhou, Zheng,et al. Stress Accelerates Defensive Responses to Looming in Mice and Involves a Locus Coeruleus-Superior Colliculus Projection[J]. CURRENT BIOLOGY,2018,28(6):859-+.
APA Li, Lei.,Feng, Xiaolong.,Zhou, Zheng.,Zhang, Huiqi.,Shi, Qianqian.,...&Wang, Liping.(2018).Stress Accelerates Defensive Responses to Looming in Mice and Involves a Locus Coeruleus-Superior Colliculus Projection.CURRENT BIOLOGY,28(6),859-+.
MLA Li, Lei,et al."Stress Accelerates Defensive Responses to Looming in Mice and Involves a Locus Coeruleus-Superior Colliculus Projection".CURRENT BIOLOGY 28.6(2018):859-+.
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