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Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats
Zhang, Limin1; Dong, Manyuan1; Xu, Guangyong1,3; Tian, Yuan1; Tang, Huiru2; Wang, Yulan1,4
2018-02-21
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume66Issue:7Pages:1723-1731
SubtypeArticle
AbstractPhenolic compounds ingestion has been shown to have potential preventive and therapeutic effects against various metabolic diseases such as obesity and cancer. To provide a better understanding of these potential benefit effects, we investigated the metabolic alterations in urine and feces of rat ingested ferulic acid (FA) and quercetin (Qu) using NMR-based metabolomics approach. Our results suggested that dietary FA and/or Qu significantly decreased short chain fatty acids and elevated oligosaccharides in the feces, implying that dietary FA and Qu may modulate gut microbial community with inhibition of bacterial fermentation of dietary fibers. We also found that dietary FA and/or Qu regulated several host metabolic pathways including TCA cycle and energy metabolism, bile acid, amino acid, and nucleic acid metabolism. These biological effects suggest that FA and Qu display outstanding bioavailability and bioactivity and could be used for treatment of some metabolic syndromes, such as inflammatory bowel diseases and obesity.
KeywordFerulic Acid Quercetin Bioavailability Bioactivity Metabolomics
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
Funding OrganizationNational Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006)
WOS KeywordPOTENTIALLY ANTICARCINOGENIC FLAVONOIDS ; HYDROCARBON RECEPTOR ACTIVATION ; GUT MICROBIOTA ; MAGNETIC-RESONANCE ; PHENOLIC-COMPOUNDS ; DISEASE ; LIVER ; TEA ; ABSORPTION ; SPECTROSCOPY
Indexed BySCI
Language英语
Funding OrganizationNational Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006)
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000426144200013
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.wipm.ac.cn/handle/112942/12865
Collection中国科学院武汉物理与数学研究所
Corresponding AuthorZhang, Limin; Tang, Huiru; Wang, Yulan
Affiliation1.Chinese Acad Sci, CAS Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China
2.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Shanghai Int Ctr Mol Phen,Zhongshan Hosp,Sch Life, Shanghai 200433, Peoples R China
3.Changzhou Univ, Sch Environm & Safety Engn, Changzhou 213164, Jiangsu, Peoples R China
4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
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GB/T 7714
Zhang, Limin,Dong, Manyuan,Xu, Guangyong,et al. Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(7):1723-1731.
APA Zhang, Limin,Dong, Manyuan,Xu, Guangyong,Tian, Yuan,Tang, Huiru,&Wang, Yulan.(2018).Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(7),1723-1731.
MLA Zhang, Limin,et al."Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.7(2018):1723-1731.
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