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Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice
Tian, Yuan1,2; Nichols, Robert G.1; Roy, Pratiti1; Gui, Wei1; Smith, Philip B.3; Zhang, Jingtao1; Lin, Yangding1; Weaver, Veronika1; Cai, Jingwei1; Patterson, Andrew D.1; Cantorna, Margherita T.1
2018-06-01
Source PublicationJOURNAL OF FUNCTIONAL FOODS
Volume45Pages:223-232
SubtypeArticle
AbstractThe mechanisms by which white button (WB) mushrooms (Agaricus bisporus) may influence health are unclear. WB feeding (1%) resulted in changes in the composition of microbiota in conventional (CV) mice to expand a population of Prevotella that produce propionate and succinate. Microbial propionate and succinate production induced expression of genes important for intestinal gluconeogenesis (IGN) via the gut-brain neural circuit. Reduced hepatic glucose production was a metabolic benefit of IGN that was found in WB fed CV mice. In the absence of microbiota or in mice with disruptions in the ability to sense microbiota there was no WB mediated effect. WB-fed lean mice had a small but significant improvement in glucose sensitivity. WB feeding resulted in shifts in the microbiota that induced IGN and improved glucose homeostasis.
KeywordMushroom Succinate Propionate Microbiota Intestinal Gluconeogenesis
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationMushroom Council ; Mushroom Council ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56AI114972 ; National Institutes of Health(R56AI114972 ; R01AT005378) ; R01AT005378) ; Mushroom Council ; Mushroom Council ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56AI114972 ; National Institutes of Health(R56AI114972 ; R01AT005378) ; R01AT005378)
DOI10.1016/j.jff.2018.04.008
WOS KeywordBRAIN NEURAL CIRCUITS ; GUT MICROBIOTA ; GLUCOSE-HOMEOSTASIS ; HOST METABOLISM ; VITAMIN-D ; OBESITY ; HEALTH ; PROPIONATE ; ERGOTHIONEINE ; SPECTROSCOPY
Indexed BySCI
Language英语
Funding OrganizationMushroom Council ; Mushroom Council ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56AI114972 ; National Institutes of Health(R56AI114972 ; R01AT005378) ; R01AT005378) ; Mushroom Council ; Mushroom Council ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56AI114972 ; National Institutes of Health(R56AI114972 ; R01AT005378) ; R01AT005378)
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000434494300026
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/11982
Collection磁共振基础研究部
Affiliation1.Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA
2.Univ Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan,CAS Key Lab Magne, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China
3.Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA
Recommended Citation
GB/T 7714
Tian, Yuan,Nichols, Robert G.,Roy, Pratiti,et al. Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice[J]. JOURNAL OF FUNCTIONAL FOODS,2018,45:223-232.
APA Tian, Yuan.,Nichols, Robert G..,Roy, Pratiti.,Gui, Wei.,Smith, Philip B..,...&Cantorna, Margherita T..(2018).Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice.JOURNAL OF FUNCTIONAL FOODS,45,223-232.
MLA Tian, Yuan,et al."Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice".JOURNAL OF FUNCTIONAL FOODS 45(2018):223-232.
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