APM OpenIR  > 磁共振应用研究部
Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods
Hu, Yili1; Zhu, Xiaoyang1; Zhao, Ruifang2; Wang, Jin1; Song, Yipeng1; Nie, Guangjun2; Tang, Huiru1,3; Wang, Yulan1,4
2018-04-01
Source PublicationNANOMEDICINE
Volume13Issue:8Pages:913-928
SubtypeArticle
AbstractAim: To evaluate the advantages of nanomaterial methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA) encapsulated doxorubicin (D/DOX) and paclitaxel (T/TAX; mPEG-PLGA-DT) over free form of DOX and TAX (DOX/TAX).Materia Is & methods: Metabonomics was conducted to characterize the systemic metabolic response of allograft breast cancer model mice to mPEG-PLGA-DT and DOX/TAX treatments. Results: Breast tumor growth induced metabolic reprogram in serum and multiple organs. DOX/TAX treatment could ameliorate the elevated energy and nucleotides demands in some organs while mPEG-PLGA-DT treatment showed outstanding therapeutic outcomes in restoring the metabolic phenotypes of serum and kidney from tumor-bearing mice to the healthy state. Conclusion: This investigation proved the biological advantages of mPEG-PLGA-DT over DOX/TAX in molecular level through the comparison between their metabolic responses in vivo.
KeywordAnticancer Drugs Biomedical Applications Metabonomics Nuclear Magnetic Resonance Nmr Polymer Nanoparticles
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Funding OrganizationNational Natural Science Foundation of China(21675169 ; National Natural Science Foundation of China(21675169 ; Ministry of Science and Technology 973(2017YFC0906800 ; Ministry of Science and Technology 973(2017YFC0906800 ; 21375144 ; 21375144 ; 2012CB934004) ; 2012CB934004) ; 91439102 ; 91439102 ; 81590953) ; 81590953) ; National Natural Science Foundation of China(21675169 ; National Natural Science Foundation of China(21675169 ; Ministry of Science and Technology 973(2017YFC0906800 ; Ministry of Science and Technology 973(2017YFC0906800 ; 21375144 ; 21375144 ; 2012CB934004) ; 2012CB934004) ; 91439102 ; 91439102 ; 81590953) ; 81590953)
DOI10.2217/nnm-2017-0363
WOS KeywordHYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; ENHANCED ANTITUMOR EFFICACY ; PLGA-PEG NANOPARTICLES ; BREAST-CANCER ; ENDOMETRIAL CARCINOMA ; GLUTATHIONE DEPLETION ; ANTICANCER DRUG ; CERVICAL-CANCER ; OVARIAN-CANCER ; LUNG-CANCER
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(21675169 ; National Natural Science Foundation of China(21675169 ; Ministry of Science and Technology 973(2017YFC0906800 ; Ministry of Science and Technology 973(2017YFC0906800 ; 21375144 ; 21375144 ; 2012CB934004) ; 2012CB934004) ; 91439102 ; 91439102 ; 81590953) ; 81590953) ; National Natural Science Foundation of China(21675169 ; National Natural Science Foundation of China(21675169 ; Ministry of Science and Technology 973(2017YFC0906800 ; Ministry of Science and Technology 973(2017YFC0906800 ; 21375144 ; 21375144 ; 2012CB934004) ; 2012CB934004) ; 91439102 ; 91439102 ; 81590953) ; 81590953)
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDWOS:000432932200008
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.apm.ac.cn/handle/112942/11979
Collection磁共振应用研究部
Affiliation1.Univ Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, CAS Key Lab Magnet Resonance Biol Syst,State Key, Wuhan 430071, Hubei, Peoples R China
2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosaftey, Beijing 100190, Peoples R China
3.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn, Metabol & Syst Biol Lab,Sch Life Sci, Shanghai 200433, Peoples R China
4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Hu, Yili,Zhu, Xiaoyang,Zhao, Ruifang,et al. Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods[J]. NANOMEDICINE,2018,13(8):913-928.
APA Hu, Yili.,Zhu, Xiaoyang.,Zhao, Ruifang.,Wang, Jin.,Song, Yipeng.,...&Wang, Yulan.(2018).Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods.NANOMEDICINE,13(8),913-928.
MLA Hu, Yili,et al."Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods".NANOMEDICINE 13.8(2018):913-928.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, Yili]'s Articles
[Zhu, Xiaoyang]'s Articles
[Zhao, Ruifang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, Yili]'s Articles
[Zhu, Xiaoyang]'s Articles
[Zhao, Ruifang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, Yili]'s Articles
[Zhu, Xiaoyang]'s Articles
[Zhao, Ruifang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.